756437-41-9|5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one| Ambeed

Yield	Reaction Conditions	Operation in experiment
77.6%	With formic acid; triethylamine;palladium dihydroxide; In methanol; at 60 - 65℃; for 3.25h;	A mixture of <strong>[109229-22-3]6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one</strong> (Intermediate 2, 18.0 g, 0.0738 mol), triethylamine (48 mL, 0.34 mol) Palladium hydroxide (10 g, 0.07 mol) in methanol (242 mL, 5.91 mol) was heated to 60 C. Formic acid (7.6 mL, 0.20 mol) was added dropwise to the mixture over a 15 minute period. The mixture was heated at at 65 C. for three hours, allowed to cool, and filtered over Celite. The filtrate was concentrated under reduced vacuum to yield the title compound as a yellow solid which was used directly in the next reaction. (9.62 g, 77.6%). MS:M+H=152.2.
77.6%		INTERMEDIATE 3 4-Chloro-5,6,7,8-tetrahydro-6-(5-methylpyridin-2-yl)pyrido[4,3-d]pyrimidineA. 5,6,7,8-Tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one[00275] A mixture of <strong>[109229-22-3]6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one</strong>(Intermediate 1, 18.0 g, 0.0738 mol), triethylamine (48 mL, 0.34 mol), palladium hydroxide (10 g, 0.07 mol) in methanol (242 mL) was heated to 60 0C. Formic acid (7.6 mL, 0.20 mol) was added dropwise to the mixture over a 15 minute period. The mixture was heated at 65 0C for three hours, allowed to cool, and filtered over Celite. The filtrate was concentrated under vacuum to yield the title compound as a yellow solid which was used as such for the next step (9.62 g, 77.6 %). MS: 152.2 [M+l]+.
	With formic acid; triethylamine;palladium(II) hydroxide; In methanol; at 60℃; for 5.5h;	Step B:To a solution of compound 1 (100 g, 0.415 mol), Pd(OH) 2 (23 g), and TEA (200 g, 2.07 mol) in MeOH(1500 mL) was added HCOOH (50 mL) dropwise at 60C over 30 mins and after addition, the mixture was stirred at 60C for additional 5 hours. The reaction mixture was cooled to room temperature and filtered over Celite. The filtrate was concentrated to yield the title compound 2 (65 g) as a yellow solid which was used directly in the next reaction. MS (ESEI): 152 (M+H)+.

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5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

CAS No.: 756437-41-9

Alternative Products

Product Details of [ 756437-41-9 ]

Safety of [ 756437-41-9 ]

Application In Synthesis of [ 756437-41-9 ]

[ 756437-41-9 ] Synthesis Path-Downstream 1~1

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