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Chemical Structure| 75561-94-3 Chemical Structure| 75561-94-3

Structure of 75561-94-3

Chemical Structure| 75561-94-3

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Product Details of [ 75561-94-3 ]

CAS No. :75561-94-3
Formula : C13H11ClN2O
M.W : 246.69
SMILES Code : O=C(NC1=CC=C(Cl)C(N)=C1)C2=CC=CC=C2
MDL No. :MFCD09047331

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Application In Synthesis of [ 75561-94-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 75561-94-3 ]

[ 75561-94-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 5131-60-2 ]
  • [ 75561-94-3 ]
YieldReaction ConditionsOperation in experiment
With benzoyl chloride; triethylamine; In dichloromethane; at 0℃; for 16h; benzoyl chloride (5.2 ml) was added to a stirred mixture of 2,4-diaminochlorobenzene (6.42 g), triethylamine (12.5 ml) and methylene chloride (100 ml) which had been cooled to 0°C. The mixture was allowed to warm to ambient temperature and was stirred for 16 hours.. The mixture was evaporated and the residue was triturated under a saturated aqueous sodium bicarbonate solution.. The resultant solid was isolated, washed in turn with water and isohexane and dried under vacuum at 55°C. There was thus obtained N-(3-amino-4-chlorophenyl)benzamide as a solid (10.38 g); NMR Spectrum: (DMSOd6) 5.32 (s, 2H), 6.9 (m, 1H), 7.1 (d, 1H), 7.37 (d, 1H), 7.52 (m, 3H), 7.9 (d, 2H), 10.05 (s, 1H).
  • 2
  • [ 107-83-5 ]
  • [ 5131-60-2 ]
  • [ 98-88-4 ]
  • [ 250683-82-0 ]
  • [ 75561-94-3 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dichloromethane; water; The N-(5-benzamido-2-chlorophenyl)-4-methoxy-2-nitrobenzamide used as a starting material was prepared as follows: Benzoyl chloride (5.2 ml) was added to a stirred mixture of 2,4-diaminochlorobenzene (6.42 g), triethylamine (12.5 ml) and methylene chloride (100 ml) which had been cooled to 0° C. The mixture was allowed to warm to ambient temperature and was stirred for 16 hours. The mixture was evaporated and the residue was triturated under a saturated aqueous sodium bicarbonate solution. The resultant solid was isolated, washed in turn with water and isohexane and dried under vacuum at 55° C. There was thus obtained N-(3-amino-4-chlorophenyl)benzamide as a solid (10.38 g); NMR Spectrum: (DMSOd6) 5.32 (s, 2H), 6.9 (m, 1H), 7.1 (d, 1H), 7.37 (d, 1H), 7.52 (m, 3H), 7.9 (d, 2H), 10.05 (s, 1H).
  • 3
  • [ 107-83-5 ]
  • [ 5131-60-2 ]
  • [ 98-88-4 ]
  • [ 75561-94-3 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dichloromethane; water; The N-(3-amino-4-chlorophenyl)benzamide used as a starting material was prepared as follows: Benzoyl chloride (5.2 ml) was added to a stirred mixture of 2,4-diaminochlorobenzene (6.42 g), triethylamine (12.5 ml) and methylene chloride (100 ml) which had been cooled to 0° C. The mixture was allowed to warm to ambient temperature and was stirred for 16 hours. The mixture was evaporated and the residue was triturated under a saturated aqueous sodium bicarbonate solution. The resultant solid was isolated, washed in turn with water and isohexane and dried under vacuum at 55° C. to yield the required compound (10.38 g); NMR 5.32 (s, 2H), 6.9 (m, 1H), 7.1 (d, 1H), 7.37 (d, 1H), 7.52 (m, 3H), 7.9 (d, 2H), 10.05 (s, 1H).
 

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