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Chemical Structure| 75510-02-0 Chemical Structure| 75510-02-0

Structure of 75510-02-0

Chemical Structure| 75510-02-0

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Product Details of [ 75510-02-0 ]

CAS No. :75510-02-0
Formula : C15H16N2
M.W : 224.30
SMILES Code : C12=C(N=CC=C2)CCN(CC3=CC=CC=C3)C1
MDL No. :MFCD01938287

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Application In Synthesis of [ 75510-02-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 75510-02-0 ]

[ 75510-02-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 253-72-5 ]
  • palladium/CaCO3 [ No CAS ]
  • [ 75510-02-0 ]
  • 2
  • [ 253-72-5 ]
  • [ 100-39-0 ]
  • [ 75510-02-0 ]
YieldReaction ConditionsOperation in experiment
With sodium borohydrid; In methanol; water; acetonitrile; 2. 6-Benzyl-5,6,7,8-tetrahydro-<strong>[253-72-5]1,6-naphthyridine</strong> 1,6-Naphthyridine (13.7 g, 105 mmol) and benzyl bromide (36.05 g, 210 mmol) were combined in acetonitrile (200 ml) and heated to reflux until no <strong>[253-72-5]1,6-naphthyridine</strong> was visible by thin layer chromatography. After removal of the solvent in vacuo, the residue was washed several times with ether and dissolved in methanol (700 ml). Water (250 ml) was added, and the solution cooled to 0°; portionwise addition of sodium borohydride (20.8 g, 550 mmol) brought about vigorous gas evolution and a slight rise in temperature. The reaction mixture was allowed to warm to room temperature and stir for 18 hours. The solvent was then removed in vacuo and the residue partitioned between water (750 ml) and methylene chloride (300 ml). The aqueous layer was extracted with additional methylene chloride (2*300 ml) and the combined organic extracts were washed once with water and once with saturated aqueous sodium chloride. Removal of solvent provided a dark amber foam, which was purified by column chromatography (99:1 methylene chloride:methanol) to yield the title product (12.1 g, 54 mmol, 51percent yield).
 

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