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Chemical Structure| 749875-03-4 Chemical Structure| 749875-03-4

Structure of 749875-03-4

Chemical Structure| 749875-03-4

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Product Details of [ 749875-03-4 ]

CAS No. :749875-03-4
Formula : C6H2ClF3IN
M.W : 307.44
SMILES Code : FC(C1=NC=CC(I)=C1Cl)(F)F
MDL No. :MFCD16610541

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Application In Synthesis of [ 749875-03-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 749875-03-4 ]

[ 749875-03-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 77332-79-7 ]
  • [ 2926-30-9 ]
  • [ 749875-03-4 ]
YieldReaction ConditionsOperation in experiment
80% With tert.-butylhydroperoxide; In dichloromethane; water; at 20℃; for 12h; To a 500 mL three-necked flask was added 250 mL of dichloromethane and 100 mL of water, and 50 g of <strong>[77332-79-7]3-chloro-4-iodopyridine</strong> (0.2 mol, 1.0 eq), 50 mL of t-butyl hydroperoxide and 180 g of sodium trifluoromethanesulfonate (1.0mol, 5eq). After the reaction was stirred at room temperature for 12 h, the methylene chloride was spin dried and slowly poured into crushed ice and stirred continuously. A large amount of white solid precipitated, filtered and the filter cake was washed three times with water. Dried and dried in vacuo to give 49 g of a white solid, 80% yield, 95% HPLC purity.
 

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