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Chemical Structure| 7495-37-6 Chemical Structure| 7495-37-6

Structure of 7495-37-6

Chemical Structure| 7495-37-6

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Product Details of [ 7495-37-6 ]

CAS No. :7495-37-6
Formula : C15H14
M.W : 194.27
SMILES Code : CC1=CC2=C(CC3=C2C=C(C)C=C3)C=C1

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Application In Synthesis of [ 7495-37-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7495-37-6 ]

[ 7495-37-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 57310-39-1 ]
  • [ 85199-06-0 ]
  • [ 7495-37-6 ]
YieldReaction ConditionsOperation in experiment
51% With N,N-dimethyl acetamide; palladium diacetate; potassium carbonate; tricyclohexylphosphine; Trimethylacetic acid; at 150℃; for 10h;Inert atmosphere; In a reactor equipped with a reflux condenser, a mixture of 3-bromo-4-chlorotoluene (compound CM20a above, 30.82 g, 150 mmol), 2,5-dimethylphenylboronic acid (compound CM20b above, 24.75 g, 165 mmol), anhydrous potassium carbonate (124.39 g, 900 mmol), palladium(II) acetate (0.67 g, 6 mmol), tricyclohexylphosphine (1.68 g, 12 mmol), dimethylacetamide (commercially available dehydrated product, 600 ml) and pivalic acid (15.32 g and 150 mmol) was stirred for 10 hours under an argon gas atmosphere while heating in an oil bath set to 150 C. After diluting with toluene (500 ml), rinsing and liquid separation were carried out 3 times using ion-exchanged water. Next, there was repeated twice a procedure of adding active white clay (product of Wako Pure Chemical Industries, Ltd., 60 g) to the obtained oil layer, stirring the mixture for 2 hours, and then passing it through Celite and a silica gel pad to remove the insolubles. After removing the solvent from the obtained solution by concentration under reduced pressure, recrystallizing purification was carried out (with a mixed solvent of chloroform and ethanol), and the deposited crystals were filtered out and dried under reduced pressure to obtain the target CM20c (35.5 g) as a solid with a faint yellow-white appearance. Yield: 51%. The HPLC-area percent value of the obtained compound CM20c measured under analysis conditions 1 was 99.3% (UV254 nm)
 

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