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Chemical Structure| 740055-30-5 Chemical Structure| 740055-30-5

Structure of 740055-30-5

Chemical Structure| 740055-30-5

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Product Details of [ 740055-30-5 ]

CAS No. :740055-30-5
Formula : C14H21NO2
M.W : 235.32
SMILES Code : N[C@H](CCC1=CC=CC=C1)C(OC(C)(C)C)=O
MDL No. :MFCD11040655

Safety of [ 740055-30-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 740055-30-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 740055-30-5 ]

[ 740055-30-5 ] Synthesis Path-Downstream   1~1

  • 1
  • t-butyl 2-oxo-4-phenylbutanoate [ No CAS ]
  • [ 740055-30-5 ]
  • [ 83079-77-0 ]
YieldReaction ConditionsOperation in experiment
A well-dried Schlenk tube charged with molecular sieves 4 Å (0.030 g), α-keto ester 8i (0.0702 g, 0.30 mmol), o-OHC6H4CH2NH2 (0.0739 g, 0.60 mmol), and catalyst 7 (0.0110 g, 0.030 mmol) was evacuated and refilled with N2. The process was repeated three times. Dry benzene (3.0 mL) was added. Upon stirring at 25 C for 48 h, the reaction mixture was concentrated. The resulting residue was treated with THF (3.0 mL), followed by the addition of aqueous 1 N HCl (3.0 mL). Upon stirring at rt for 5 h, the mixture was diluted with water (10 mL) then washed with hexane (3×10 mL). The organic phase was extracted with aqueous 1 N HCl. The aqueous phases were combined, brought to pH 8.0 with solid NaHCO3, extracted with CH2Cl2 (5×10 mL), and the organic extracts were dried (MgSO4), filtered, concentrated, and purified by flash chromatography (silica gel, petroleum ether/EtOAc=5/1 then EtOAc/CH3OH=10/1) to give α-amino ester 11i (0.0607 g, 86% yield); +13.1 (c 0.89, CHCl3) (57% ee).
 

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