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Chemical Structure| 7298-21-7 Chemical Structure| 7298-21-7

Structure of 7298-21-7

Chemical Structure| 7298-21-7

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Product Details of [ 7298-21-7 ]

CAS No. :7298-21-7
Formula : C9H10O4
M.W : 182.17
SMILES Code : CC(C1=CC(OC)=C(O)C=C1O)=O
MDL No. :MFCD22056102

Safety of [ 7298-21-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 7298-21-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7298-21-7 ]

[ 7298-21-7 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 6100-60-3 ]
  • [ 75-05-8 ]
  • [ 7298-21-7 ]
  • 2
  • [ 6100-60-3 ]
  • [ 64-19-7 ]
  • [ 7298-21-7 ]
YieldReaction ConditionsOperation in experiment
77% With boron trifluoride diethyl etherate; at 20 - 120℃; for 12h;Inert atmosphere; To a stirred solution of <strong>[6100-60-3]4-methoxybenzene-1,3-diol</strong> 1 (1 g, 7.14 mmol) in HOAc (100 mL) atRT under an inert atmosphere, was added BF3.Et20 (1.07 mL, 8.57 mmol). The mixture was heated to 120 C for 12 h. The mixture was cooled to RT then diluted with water (30 mL) and extracted with EtOAc (2 x 40 mL). The combined organic extracts were washed with brine (25 mL), dried (Na2SO4), filtered and concentrated under reduced pressure. The residue was purified (silica gel; eluting 10% EtOAc/hexanes) to afford compound 2 (1 g, 77%) as an off white solid.
  • 3
  • [ 6100-60-3 ]
  • [ 75-36-5 ]
  • [ 7298-21-7 ]
YieldReaction ConditionsOperation in experiment
86% With boron trifluoride diethyl etherate; for 3h;Inert atmosphere; General procedure: BF3·OEt2 (1.0 mol equiv.) was added to a solution of phenols9a-c (2.0 mol equiv. for 9a-b and 1.0 mol equiv. for9c) and the corresponding acyl chloride (2.0 mol equiv.)under nitrogen atmosphere at 0 C. The mixture was thenstirred at 80 C for 3 h. After pouring the residue into icewater (10 mL), adjusted to neutral pH with an aqueoussaturated solution of NaHCO3, and extracted with EtOAc(3 × 30 mL). The organic layer was dried over Na2SO4 andconcentrated under reduced pressure, followed by purifying the residue by column chromatography over silica gel(hexane/EtOAc, 9:1) to give the respective acyl phenols 6-8(Mendieta et al. 2014).
 

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