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Chemical Structure| 72948-86-8 Chemical Structure| 72948-86-8

Structure of 72948-86-8

Chemical Structure| 72948-86-8

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Product Details of [ 72948-86-8 ]

CAS No. :72948-86-8
Formula : C9H13NO
M.W : 151.21
SMILES Code : N#CC12CCC(O)(CC1)CC2
MDL No. :MFCD28347502

Safety of [ 72948-86-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 72948-86-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 72948-86-8 ]

[ 72948-86-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1127-13-5 ]
  • [ 72948-86-8 ]
YieldReaction ConditionsOperation in experiment
90% To a cooled (-300C) solution of the title compound from the Preparative Example 81, Step A (540 mg) and NEt3 (590 muL) in THF (35 mL) was added ethyl chloroformate (320 muL). The mixture was stirred at -30C for 1 h and then filtered. The precipitated salts were washed with THF (20 mL). The combined filtrates were cooled to -20C and a 33% solution Of NH3 in H2O (10 mL) was added. The mixture was stirred at -2O0C for 20 min, then the cooling bath was removed and the mixture was stirred at room temperature for 40 min. The mixture was concentrated and dissolved in THF/CH3CN (4:1, 25 mL). Pyridine (1.26 mL) was added and the mixture was cooled to O0C. Trifluoroacetic anhydride (1.10 mL) was added and the mixture was stirred at O0C for 2 h. Then the mixture was concentrated to 5 mL, diluted with MeOH (18 mL) and 10% aqueous K2CO3 (9 mL), stirred at room temperature overnight, concentrated to 10 mL, acidified to pH 1 with IN aqueous HCl and extracted with CH2Cl2 (4 x 75 mL). The combined organic phases were dried (MgSO4), filtered, concentrated and purified by chromatography (silica, CH2Cl2/Me0H) to afford the title compound (433 mg, 90%). [MH]+ = 152.
 

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