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Chemical Structure| 7272-54-0 Chemical Structure| 7272-54-0

Structure of 7272-54-0

Chemical Structure| 7272-54-0

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Product Details of [ 7272-54-0 ]

CAS No. :7272-54-0
Formula : C13H16N2O2
M.W : 232.28
SMILES Code : O=C(C1=CC2=C(NC=C2CCN)C=C1)OCC

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Application In Synthesis of [ 7272-54-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7272-54-0 ]

[ 7272-54-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 29882-07-3 ]
  • [ 40566-85-6 ]
  • [ 7272-54-0 ]
YieldReaction ConditionsOperation in experiment
In ethanol; water; b. 2-(5-Carboethoxy-1H-indol-3-yl)ethylamine A solution of ethyl-p-hydrazinobenzoate hydrochloride (10 g, 46 mmol) and <strong>[29882-07-3]4-chlorobutanal dimethyl acetal</strong> (7.8 g, 46 mmol) in ethanol/water (5:1, 500 ml) was heated at reflux for 2 hours. The solvent was removed under vacuum and the residue chromatographed through silica gel eluding with dichloromethane/ethanol/ammonia (40:8:1) to give the title indole (3.69 g) as an oil. NMR delta (360 MHz, CDCl3) 1.42 (3H, t, J=7 Hz), 2.94 (2H, t, J=7 Hz), 3.06 (2H, t, J=7 Hz), 4.40 (2H, q, J=7 Hz), 7.10 (1H, br s), 7.35 (1H, d, J=9 Hz), 7.91 (1H, dd, J=9 and 2 Hz), 8.30 (1H, br s), 8.38 (1H, s).
 

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