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Chemical Structure| 723286-80-4 Chemical Structure| 723286-80-4

Structure of 723286-80-4

Chemical Structure| 723286-80-4

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Product Details of [ 723286-80-4 ]

CAS No. :723286-80-4
Formula : C10H15BrN4O2
M.W : 303.16
SMILES Code : O=C(N1CC2=NN=C(Br)N2CC1)OC(C)(C)C
MDL No. :MFCD08448169
InChI Key :SSOWVJRCWPTTLK-UHFFFAOYSA-N
Pubchem ID :17998723

Safety of [ 723286-80-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 723286-80-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 723286-80-4 ]

[ 723286-80-4 ] Synthesis Path-Downstream   1~3

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  • [ 723286-79-1 ]
  • [ 723286-80-4 ]
YieldReaction ConditionsOperation in experiment
51% With N-Bromosuccinimide; sodium hydrogencarbonate; In chloroform; at 0 - 20℃; for 2h; The compound obtained in Step 3 (1 g) was dissolved in chloroform (20 mL), sodium bicarbonate (688 mg) and N- bromosuccinimide (873 mg) was added at 0 C., the-reaction solution was stirred for 2 hours at room temperature and extracted 3 times with chloroform after addition of water, the organic layer gave the title compound by the residue obtained, which was concentrated after drying over sodium sulfate and purified by silica gel column chromatography (693mg, 51%). LRMS (ESI) m / z 303 [M + H] +.
With N-Bromosuccinimide; sodium hydrogencarbonate; In chloroform; at 0 - 20℃; for 16h; To a solution of 9.01 g (40.0 mmol) of 7- (tert-butoxycarbonyl)-5, 6,7, 8- tetrahydro [1, 2,4] triazolo [4, 3-a] pyrazine in 150 mL chloroform was added 6.72 g (80.0 mmol) of sodium bicarbonate. The system was cooled to 0 C and 7.11 g (40.0 mmol) OF N- bromosuccinimide was added. The reaction was stirred at 0 C for 15 min and at ambient temperature for 16 h. The reaction was diluted with dichloromethane and washed sequentially with saturated aqueous sodium bicarbonate solution and brine, dried over magnesium sulfate, and concentrated in vacuo. The crude product was purified by flash chromatography on a BIOTAGE system (silica gel, 4% methanol/ethyl acetate) to yield the title compound. LC/MS 303.0 and 305.0 (M+1).
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  • [ 274-82-8 ]
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Technical Information

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[ 723286-80-4 ]

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Amides

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Related Parent Nucleus of
[ 723286-80-4 ]

Other Aromatic Heterocycles

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A208098 [723286-79-1]

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