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Chemical Structure| 72135-20-7 Chemical Structure| 72135-20-7

Structure of 72135-20-7

Chemical Structure| 72135-20-7

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Product Details of [ 72135-20-7 ]

CAS No. :72135-20-7
Formula : C19H29N3O4S
M.W : 395.52
SMILES Code : O=C(NCC1N(CC2CC2)CCC1)C3=CC(S(=O)(CC)=O)=C(N)C=C3OC

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Application In Synthesis of [ 72135-20-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 72135-20-7 ]

[ 72135-20-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 71675-87-1 ]
  • [ 541-41-3 ]
  • [ 71820-57-0 ]
  • [ 72135-20-7 ]
YieldReaction ConditionsOperation in experiment
66.5% With triethylamine; In tetrahydrofuran; water; N-(1-cyclopropyl-methyl-2-pyrrolidinyl-methyl)-2-methoxy-4-amino-5-ethylsulphonyl-benzamide 31.3 g (0.31 mole) of triethylamine, 400 ml of tetrahydrofuran and 80.3 g (0.31 mole) of <strong>[71675-87-1]2-methoxy-4-amino-5-ethylsulphonyl benzoic acid</strong> are placed in a 1 liter flask fitted with an agitator, a thermometer, a condenser and a dropping funnel. A rubbery precipitate is formed which gradually crumbles. After 30 minutes at room temperature it is cooled to 0° C. and 33.6 g (0.31 mole) of ethyl chloroformate is added drop by drop. This is kept under agitation for 1 hour between 0° and 5° C. and 62 g (0.40 mole) of 1-(cyclopropylmethyl)-2-amino-methyl-pyrrolidine is added drop by drop while the temperature is kept at the same level. A thick precipitate is formed. The reaction medium is agitated for a further 2 hours at room temperature then left to stand overnight. The crystals obtained are filtered, washed twice with 100 ml of tetrahydrofuran and dried in an oven at 50° C. 137 g of product is obtained and is dissolved with boiling water. After filtering and drying, 91 g (74.3percent) of crystals is obtained; these are re-crystallized in 600 ml of 90percent alcohol. They are filtered, washed twice with 50 ml of alcohol and dried in an oven at 40° C. 81.5 g (yield 66.5percent) of N-(1-cyclopropylmethyl-2-pyrrolidinyl-methyl)-2-methoxy-4-amino-5-ethylsulphonyl benzamide is obtained, melting at 181° C.
 

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