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Chemical Structure| 7119-08-6 Chemical Structure| 7119-08-6

Structure of 7119-08-6

Chemical Structure| 7119-08-6

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Product Details of [ 7119-08-6 ]

CAS No. :7119-08-6
Formula : C9H4BrF3
M.W : 249.03
SMILES Code : FC(F)(F)C#CC1=CC(Br)=CC=C1
MDL No. :MFCD30470980

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Application In Synthesis of [ 7119-08-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7119-08-6 ]

[ 7119-08-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 29835-28-7 ]
  • [ 81290-20-2 ]
  • [ 7119-08-6 ]
YieldReaction ConditionsOperation in experiment
53% General procedure: A mixture of CuI (76 mg, 0.4 mmol), phen (79 mg, 0.4 mmol), Ag2CO3 (220 mg, 0.8 mmol), KF (69 mg, 1.2 mmol) and DMF (6 mL) was added to a 25 mL round-bottom flask that was equipped with a magnetic stir bar at room temperature in a glove box. The round bottom flask was sealed with a rubber plug and taken out. Then the flask was evacuated and refilled with nitrogen for three times. Next, Me3SiCF3 (294 mL, 2.0 mmol) was added to the mixture dropwise in 5 min and the mixture was stirred at room temperature for 30 min. A solution of arylpropiolic acids (0.4 mmol) in 1.0 mL DMF was added to the flask during 4 h by using a syringe pump at room temperature. After the addition, the reaction mixture was kept for another 2 h at room temperature. At the end of reaction, dichloromethane (DCM) was added to the reaction system. The organic layer was separated and washed with water three times. The combined organic extracts was dried over Na2SO4 for 2 h and then concentrated under vacuum. After evaporation, the residue was purified by silica gel column chromatography with petroleum ether to provide pure desired products.
 

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