Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 693248-53-2 | MDL No. : | MFCD13193581 |
Formula : | C6H8O3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | JVRUZPDYVLRYQT-UHFFFAOYSA-N |
M.W : | 128.13 | Pubchem ID : | 12204422 |
Synonyms : |
|
Num. heavy atoms : | 9 |
Num. arom. heavy atoms : | 0 |
Fraction Csp3 : | 0.83 |
Num. rotatable bonds : | 1 |
Num. H-bond acceptors : | 3.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 29.58 |
TPSA : | 46.53 Ų |
GI absorption : | High |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -7.32 cm/s |
Log Po/w (iLOGP) : | 1.17 |
Log Po/w (XLOGP3) : | -0.33 |
Log Po/w (WLOGP) : | -0.04 |
Log Po/w (MLOGP) : | 0.0 |
Log Po/w (SILICOS-IT) : | 0.38 |
Consensus Log Po/w : | 0.24 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.56 |
Log S (ESOL) : | -0.36 |
Solubility : | 55.9 mg/ml ; 0.436 mol/l |
Class : | Very soluble |
Log S (Ali) : | -0.19 |
Solubility : | 83.5 mg/ml ; 0.652 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | 0.36 |
Solubility : | 291.0 mg/ml ; 2.27 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 2.94 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P280-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H332-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide; at 25.0℃; for 16.0h; | General procedure: These examples were synthesized using library format. To individual acid (0.07 8 mmol) in DMF (1 ml) was added DIEA (0.027 ml) then 0.266 ml T3P solution (50% in EtOAc). The solution was then treated with a 0.025 ml solution of amine (24 mg, from a solution of 576 mg amine 4 in 0.6 ml DMF). The solution was stirred at room temp for 16 h. The reaction was filtered into a 96 well plate and submitted to high throughput purification.Purification method for amides:Column: Waters Sunfire C18, 5u, 19x100 mm50m1/min8 minute run timeMobile phase A = Water + .1% Formic AcidMobile phase B = MeCN + .1% Formic AcidGradient from 10 to 75% MeCN. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20.0℃; | General procedure: A solution of tert-butyl (2-amino-4-(4-fluorophenyl)phenyl)carbamate (12.1 g, 40.1 mmol,0.9 eq.), tetrahydro-2H-pyran-4-carboxylic acid (6.0 g, 46.1 mmol, 1.0 eq.), HATU (21.0g, 55.3 mmol, 1.2 eq.) and Huenigs base (16.1 mL, 92.3 mmol, 2.0 eq.) in DMF (60 mL) was stirred at room temperature. After completion, the reaction mixture was diluted with water. The solid was isolated by filtration and washed with pentane to afford tert-butyl (2-(tetrahydro-2H-pyran-4-carboxamido)-4-(thiophen-2-yl)phenyl)carbamate (15.1 g, 79 %yield). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
45% | With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 25.0℃; for 12.0h; | A mixture of 3-oxabicyclo[3.1.0]hexane-6-carboxylicacid (trans, 300 mg, 2.34 mmol), Nu,Omicron- dimethylhydroxylamine hydrochloride (297 mg, 3.04 mmol), l-[bis(dimethylamino)methylene]-lH- l,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (1157 mg, 3.04 mmol) and N,N- diisopropylethylamine (756 mg, 5.85 mmol) in N,N-dimethylformamide (15 mL) was stirred at 25 C for 12 h. The reaction mixture was diluted with water (30 mL) and extracted with ethyl acetate (3 x 15 mL). The combined organic layers were washed with water (2 x 10 mL), brine (20 mL) and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, 100-200 mesh, 0 to 30% ethyl acetate in petroleum ether) to give N-methoxy-N-methyl-3- oxabicyclo[3.1.0]hexane-6-carboxamide (180 mg, 45%) as a colorless oil. NMR (400 MHz, CDCl3) delta 3.95 - 3.93 (m, 2H), 3.80 - 3.78 (m, 2H), 3.73 (s, 3H), 3.20 (s, 3H), 2.17 - 2.09 (m, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With water; sodium hydroxide; In tetrahydrofuran; at 20℃;Cooling with ice; | <strong>[335599-07-0]3-oxabicyclo[3.1.0]hexane-6-carboxylic acid ethyl ester</strong>(4.26g, 27.3mmol) dissolved in 100mL tetrahydrofuran,An aqueous sodium hydroxide solution was added dropwise to it under ice water bath(50mL, 81.9mmol), react at room temperature overnight. Adjust the pH to 3 with dilute hydrochloric acid,After removing the organic solvent, freeze-dry. Wash the lyophilized mixture with methanol and filter with suction,After the filtrate was dried over anhydrous sodium sulfate, it was concentrated under reduced pressure and used directly in the next reaction. |
[ 5337-03-1 ]
Tetrahydropyran-4-yl-carboxylic acid
Similarity: 0.93
[ 233276-38-5 ]
4-Methyltetrahydro-2H-pyran-4-carboxylic acid
Similarity: 0.89
[ 138498-97-2 ]
2-(Tetrahydrofuran-3-yl)acetic acid
Similarity: 0.89
[ 873397-34-3 ]
Tetrahydro-2H-pyran-3-carboxylic acid
Similarity: 0.86
[ 85064-61-5 ]
Tetrahydropyranyl-4-acetic acid
Similarity: 0.85
[ 5337-03-1 ]
Tetrahydropyran-4-yl-carboxylic acid
Similarity: 0.93
[ 335599-07-0 ]
Ethyl 3-oxa-bicyclo[3.1.0]hexane-6-carboxylate
Similarity: 0.90
[ 233276-38-5 ]
4-Methyltetrahydro-2H-pyran-4-carboxylic acid
Similarity: 0.89
[ 138498-97-2 ]
2-(Tetrahydrofuran-3-yl)acetic acid
Similarity: 0.89
[ 5617-74-3 ]
3-Oxabicyclo[3.1.0]hexane-2,4-dione
Similarity: 0.87
[ 335599-07-0 ]
Ethyl 3-oxa-bicyclo[3.1.0]hexane-6-carboxylate
Similarity: 0.90
[ 5617-74-3 ]
3-Oxabicyclo[3.1.0]hexane-2,4-dione
Similarity: 0.87
[ 67911-21-1 ]
6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione
Similarity: 0.84
[ 14166-28-0 ]
(3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione
Similarity: 0.76
[ 41088-52-2 ]
Methyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate
Similarity: 0.73