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[ CAS No. 690635-35-9 ] Ethyl 4-amino-6-chloro-5-nitronicotinate

Cat. No.: A844657
Chemical Structure| 690635-35-9
Chemical Structure| 690635-35-9
Structure of 690635-35-9 * Storage: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Purity Size Price USA Stock *0-1 Day Global Stock *5-7 Days Quantity
95% 100mg $96.00 Inquiry Inquiry
95% 250mg $162.00 Inquiry Inquiry
95% 1g $436.00 Inquiry Inquiry

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* Storage: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

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Product Details of [ 690635-35-9 ]

CAS No. :690635-35-9 MDL No. :MFCD14581634
Formula : C8H8ClN3O4 Boiling Point : No data available
Linear Structure Formula :- InChI Key :-
M.W : 245.62 Pubchem ID :-
Synonyms :

Safety of [ 690635-35-9 ]

Signal Word:Warning Class:
Precautionary Statements:P280-P305+P351+P338 UN#:
Hazard Statements:H302 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 690635-35-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 690635-35-9 ]

[ 690635-35-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 154012-15-4 ]
  • [ 690635-35-9 ]
YieldReaction ConditionsOperation in experiment
52.6% With ammonia; In 1,4-dioxane; dichloromethane; at 0 - 20℃; for 24h; Step 4: Preparation of ethyl 4-amino-6-chloro-5-nitronicotinate (17) To a solution of <strong>[154012-15-4]ethyl 4,6-dichloro-5-nitronicotinate</strong> 16 (15.0 g, 56.6 mmol) in dichloromethane 85 ml was added saturated ammonia solution in 1,4-dioxane 115 ml at 0 C. The resulting mixture was then stirred at ambient temperature for 24 h. Solvent was removed under reduced pressure and the residue was subjected to silica gel column chromatography using ether/ethyl acetate (15:1) as eluent to give 17 7.3 g as yellow crystalline solid, yield 52.6%. Mp 118-120 C. 1H NMR (300 MHz, DMSO-d6), delta (ppm): 8.62 (s, 1H), 8.05 (br s, 2H), 4.33 (q, J = 6.0 Hz, 2H), 1.31 (t, J = 6.0 Hz, 3H). MS (ESI(+) 70 V) m/z: 246 [M+H]+.
With ammonia; triethylamine; In 1,4-dioxane; dichloromethane; at 0℃; To a solution of 4,6-Dichloro-2-methyl-5-nitro-pyridine-3-carboxylic acid (15 g, 56.6 mmol) and triethylamine (7.9 ML, 57.3 mmol) in dichloromethane (84 ML) at 0 C. was added dropwise ammonia solution in dioxane (0.5 M, 113 ML, 56.5 mmol).The mixture was then stirred overnight.Removal of the solvent followed by column chromatography gave 9 as a yellow crystalline solid. (7.3 g).1H-NMR delta: 1.32 (t, J=7.1 Hz, 3H), 4.33 (q, J=7.1 Hz, 2H), 8.06 (s, br, 2H), 8.62 (s, 1H).
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