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Chemical Structure| 6853-29-8 Chemical Structure| 6853-29-8

Structure of 6853-29-8

Chemical Structure| 6853-29-8

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Product Details of [ 6853-29-8 ]

CAS No. :6853-29-8
Formula : C8H10N2O2
M.W : 166.18
SMILES Code : NC1=CC=C([N+]([O-])=O)C=C1CC
MDL No. :MFCD25966163

Safety of [ 6853-29-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 6853-29-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6853-29-8 ]

[ 6853-29-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 33098-65-6 ]
  • [ 6853-29-8 ]
  • [ 20191-74-6 ]
YieldReaction ConditionsOperation in experiment
Step 1 N-(2-Ethyl-4-nitrophenyl)acetamide and N-(2-ethyl-5-nitrophenyl)acetamide [0168] Sulfuric acid (30 mL, 563 mmol) was cooled to 0° C. and N-(2-ethylphenyl)acetamide (2 g, 12.3 mmol) was added in several portions. To the resulting solution was added potassium nitrate (1.24 g, 12.3 mmol). The reaction mixture was allowed to warm to room temperature and stirred overnight. The reaction mixture was poured over ice slowly. The resulting solid was collected by filtration to give white solid containing both N-(2-ethyl-4-nitrophenyl)acetamide and N-(2-ethyl-5-nitrophenyl)acetamide (2.0 g, 9.61 mmol, 78.4percent) which was directly used for the next step without further purification. Step 2 2-Ethyl-5-nitroaniline and 2-ethyl-4-nitroaniline [0169] A solution of the mixture of N-(2-ethyl-4-nitrophenyl)acetamide and N-(2-ethyl-5-nitrophenyl)acetamide (2 g, 9.61 mmol) in concentrated hydrobromic acid (40 mL) was heated at 110° C. for 8 h. The reaction mixture was cooled to room temperature. After partial removal of solvent, the mixture was diluted with EtOAc and ice water. Saturated aqueous sodium carbonate was slowly added. The organic phase was washed with sodium carbonate and brine, dried over Na2SO4, filtered and concentrated in vacuo to give the crude mixture of 2-ethyl-5-nitroaniline and 2-ethyl-4-nitroaniline (1.5 g, 9.03 mmol, 94.0percent) as a yellow solid which was directly used for the next step without purification.
  • 2
  • [ 14150-94-8 ]
  • [ 107-87-9 ]
  • [ 217302-90-4 ]
  • [ 6853-29-8 ]
  • C8H10N2O2 [ No CAS ]
 

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