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Chemical Structure| 676254-89-0 Chemical Structure| 676254-89-0

Structure of 676254-89-0

Chemical Structure| 676254-89-0

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Product Details of [ 676254-89-0 ]

CAS No. :676254-89-0
Formula : C14H19NO3
M.W : 249.31
SMILES Code : O=C(N1CCCC2=C1C=C(O)C=C2)OC(C)(C)C

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Application In Synthesis of [ 676254-89-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 676254-89-0 ]

[ 676254-89-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 58196-33-1 ]
  • [ 24424-99-5 ]
  • [ 676254-89-0 ]
YieldReaction ConditionsOperation in experiment
40% With triethylamine; In dichloromethane; at 45℃; for 48h; To a suspension of l,2,3,4-tetrahydro-quinolin-7-ol (0.50 g, 3.35 mmol) in dichloromethane (40 ml) were added di-tert-butyldicarbonate (1.54 g, 7.04 mmol) and triethylamine (1.86 ml, 13.4 mmol) and the reaction mixture was stirred at 45 0C for 48 h. The mixture was then acidified to pH 6 by addition of 10% aq. citric acid solution and extracted with dichloromethane. The combined organic phases were washed with <n="35"/>saturated brine, dried over sodium sulphate, and concentrated in vacuo. The residue was dissolved in methanol (40 ml) and aq. sodium hydroxide solution (6.70 ml, 13.4 mmol, 2 M) was added. After stirring for 16 h at 60 0C, the mixture was cooled to room temperature and acidified to pH 6 by addition of 10% aq. citric acid solution and extracted with dichloromethane. The combined organic phases were dried over sodium sulphate and concentrated in vacuo to yield the title compound as a colourless oil which was used in the next step without further purification (0.33 g, 40%); MS (ISP): 250.3 ( [M+H]+), 194.4 ([M+H-Me2C=CH2]+).
 

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