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Chemical Structure| 67483-73-2 Chemical Structure| 67483-73-2

Structure of 67483-73-2

Chemical Structure| 67483-73-2

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Product Details of [ 67483-73-2 ]

CAS No. :67483-73-2
Formula : C14H11ClO2
M.W : 246.69
SMILES Code : ClC1=CC=C(C(OCC2=CC=CC=C2)=O)C=C1
MDL No. :MFCD00791366

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Application In Synthesis of [ 67483-73-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 67483-73-2 ]

[ 67483-73-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2905-56-8 ]
  • [ 762-42-5 ]
  • [ 74-11-3 ]
  • [ 67483-73-2 ]
  • [ 4606-55-7 ]
YieldReaction ConditionsOperation in experiment
93% In dichloromethane; at 20℃; for 14h; General procedure: At room temperature, organic carbonyl acid 3 (R-COOH, 0.5 mmol) was added into a reaction tube equipped with a small magnet. Then a solution of tertiary amine 1 (R1CH2-NR2R3, 0.5 mmol ) in DCM (2.5 mL) was added dropwise in 2 min. After the mixture was stirred at room temperature for a few minutes, 1 equivalents of dimethyl acetylenedicarboxylate (DMAD, 2) was added. The reaction was stirred overnight at room temperature, and then monitored by TLC with silica gel coated plates. After being stirred for 14 h, the solvent was removed and the residue was purified by a flash column chromatography with silica gel with ethyl acetate/hexane (1:25-30) as eluent to give the desired products 4, 5, and 7. Most of compounds are known and confirmed by NMR, ESI-MS, IR.
 

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