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Chemical Structure| 651043-20-8 Chemical Structure| 651043-20-8

Structure of 651043-20-8

Chemical Structure| 651043-20-8

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Product Details of [ 651043-20-8 ]

CAS No. :651043-20-8
Formula : C13H12N2O
M.W : 212.25
SMILES Code : O=C1N=C(C2CC2)NC(C3=CC=CC=C3)=C1

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Application In Synthesis of [ 651043-20-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 651043-20-8 ]

[ 651043-20-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 94-02-0 ]
  • [ 57297-29-7 ]
  • [ 651043-20-8 ]
YieldReaction ConditionsOperation in experiment
To 5 ml of methanol, 4 g of sodium methoxide (28percent methanol solution), 0.75 g of <strong>[57297-29-7]cyclopropanecarboxamidine hydrochloride</strong> and 1 g of benzoylacetic acid ethyl ester were added. This mixture was heated under reflux for 20 hours. The reaction mixture was left standing to cool and then concentrated. To the residue, 10percent hydrochloric acid was added, followed by extraction three times with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and then concentrated. The residue was washed with hexane to obtain 0.39 g of 2- cyclopropyl-6-phenylpyrimidin-4-ol . 2-cyclopropyl-6-phenylpyrimidin-4-ol1H-NMR (DMSO-de): 1.04-1.16 (m, 4H) , 1.93-1.99 (m, IH) ,6.64(s, IH), 7.43-7.47 (m, 3H), 7.94-7.99 (m, 2H) , 12.67(bs,lH)
  • 2
  • [ 57297-29-7 ]
  • [ 637-44-5 ]
  • [ 651043-20-8 ]
 

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