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Chemical Structure| 6480-67-7 Chemical Structure| 6480-67-7

Structure of 6480-67-7

Chemical Structure| 6480-67-7

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Product Details of [ 6480-67-7 ]

CAS No. :6480-67-7
Formula : C10H8N2O
M.W : 172.18
SMILES Code : O=C(C1=CC2=CC=CC=C2N=C1)N
MDL No. :MFCD01366544

Safety of [ 6480-67-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 6480-67-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6480-67-7 ]

[ 6480-67-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 53951-84-1 ]
  • [ 6480-67-7 ]
YieldReaction ConditionsOperation in experiment
59% With ammonia; In water; at 20℃; for 6h; A solution of 12C-8b (110 mg, 0.59 mmol) in 25% aqua ammonia (2.0 mL) was stirred at room temperature for 6 hours. Then the solution was purred into water and extracted with ethyl acetate and washed with brine. The combined organic layer was dried over Na2SO4 and passed through a short silica gel column (2.0 g) to give quinoline-3-carboxamide (12C-13f) (60 mg, 59% yield) as a colorless powder: 1H NMR (300 MHz, CDCl3) d 9.3 (d, J = 2.2 Hz, 1H), 8.67 (d, J = 1.5 Hz, 1H), 8.17 (d, J = 8.4 Hz, 1H), 7.94 (d, J = 8.4 Hz, 1H), 7.84 (dd, J = 7.0, 8.1 Hz, 1 H), 7.64 (dd, J = 7.0, 8.1 Hz, 1 H), 6.5 - 5.8 (br, 2H); 13C NMR (75 MHz, CDCl3) d 167.25, 149.50, 148.22, 136.35, 131.61, 129.46, 128.88, 127.68, 126.86, 125.82. GC-MS (EI) [M]+ 172, [M-NH2]+ 156, [M-CONH2]+ 128.
 

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