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Chemical Structure| 64224-61-9 Chemical Structure| 64224-61-9

Structure of 64224-61-9

Chemical Structure| 64224-61-9

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Product Details of [ 64224-61-9 ]

CAS No. :64224-61-9
Formula : C8H10N2O2S
M.W : 198.24
SMILES Code : O=C(C1=NC=NC=C1SC)OCC
MDL No. :MFCD16660481

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Application In Synthesis of [ 64224-61-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 64224-61-9 ]

[ 64224-61-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 144-55-8 ]
  • [ 64224-60-8 ]
  • [ 64224-61-9 ]
YieldReaction ConditionsOperation in experiment
With trifluoroborane diethyl ether; In ethanol; dichloromethane; Ethyl 5-methylthiopyrimidine-4-carboxylate can be prepared by heating a solution of <strong>[64224-60-8]5-bromopyrimidine-4-carboxylic acid</strong> (3.4 g) in ethanol (34 cc) and boron trifluoride etherate (7.4 g) under reflux for 20 hours. After concentration to dryness under reduced pressure (20 mm Hg), methylene chloride (50 cc) is added to the residue and neutralisation is effected by the addition of an 8% (w/v) aqueous sodium bicarbonate solution. The aqueous phase is decanted and extracted with methylene chloride (50 cc). The combined organic phases are dried over sodium sulphate, filtered and evaporated under reduced pressure. Ethyl-5-methylthiopyrimidine-4-carboxylate (3.7 g), melting at 99-100 C, is thus obtained.
 

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