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Chemical Structure| 64189-17-9 Chemical Structure| 64189-17-9

Structure of 64189-17-9

Chemical Structure| 64189-17-9

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Product Details of [ 64189-17-9 ]

CAS No. :64189-17-9
Formula : C10H9F3O
M.W : 202.17
SMILES Code : OCC=CC1=CC=CC(C(F)(F)F)=C1
MDL No. :MFCD09260892

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Application In Synthesis of [ 64189-17-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 64189-17-9 ]

[ 64189-17-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 87087-35-2 ]
  • [ 64189-17-9 ]
YieldReaction ConditionsOperation in experiment
(91-1) Synthesis of 3-(3-trifluoromethylphenyl)-2-propene-1-ol (compound 91-1) 3-(3-Trifluoromethylphenyl)acrylic acid (3.0 g) was dissolved in methanol (30 ml), concentrated sulfuric acid (0.5 ml) was added, and the mixture was stirred at 100C for 5.5 hr. The reaction mixture was concentrated, and the residue was washed with water. The obtained white powder was dissolved in tetrahydrofuran (40 ml), 1M diisobutylaluminum hydride/toluene solution (26 ml) was added dropwise at -78C, and the mixture was stirred as it was at -78C for 2 hr. Saturated Rochelle salt water, water and ethyl acetate were added to the reaction mixture, and the mixture was stirred at room temperature, extracted with ethyl acetate, washed with water and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate) to give the object product (2.0 g) as a colorless oil. 1H-NMR(DMSO-d6) δ (ppm): 4.15 (2H, td, J=4.9, 0.9Hz), 4.96(1H, t, J=5.5Hz), 6.57(1H, dt, J=16.0, 4.6Hz), 6.67(1H, d, J=15.9Hz), 7.55-7.67(2H, m), 7.75(2H, s).
 

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