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Chemical Structure| 636589-63-4 Chemical Structure| 636589-63-4

Structure of 636589-63-4

Chemical Structure| 636589-63-4

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Product Details of [ 636589-63-4 ]

CAS No. :636589-63-4
Formula : C19H16F3NOS2
M.W : 395.46
SMILES Code : FC(F)(C1=CC=C(C2=NC(C)=C(CSC3=CC=C(C(C)=C3)O)S2)C=C1)F

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Application In Synthesis of [ 636589-63-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 636589-63-4 ]

[ 636589-63-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 439134-78-8 ]
  • [ 636589-63-4 ]
YieldReaction ConditionsOperation in experiment
87% 4-Iodo-2-methylphenol (3.90 g, 16.7 mmol) was dissolved in anhydrous tetrahydrofuran (120 mi) under nitrogen atmosphere and the temperature was maintained at 0 °C . Isopropyl magnesium chloride (9.17 mi, 2M-ether solution, 1.1 eq.) was added to the above mixture slowly and reacted for 10 minutes. After cooling the reaction mixture to -78 °C , tert-butyl lithium (21.6 mi, 1.7M-heptane solution, 2.2 eq.) was added slowly and the reaction mixture was reacted for another 20 minutes. A solution of sulfur (534 mg, 17.0 mmol, 1.0 eq.) in anhydrous THF (15 m*) was added to the reaction mixture slowly and reacted unitl the temperature became 0 °C . After 60 minutes, the temperature of the reaction mixture was adjusted at 0°C and 5- bromomethyl-4-methyl-2-[(4-trifluoromethyl)phenyl]-thiazole of formula (VIII) (5.14 g, 15.0 mmol, 0.9 eq.) dissolved in anhydrous THF (12 mi) was added slowly. The reaction mixture was reacted for around 30 minutes, followed by adding aqueous ammonium chloride solution (150 mi) to complete the reaction. The resultant organic layer was separated and dried over magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane : ethyl acetate = 3 : 1) to thereby yield 5.85 g of the title compound (yield: 87percent)
 

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