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Chemical Structure| 633283-63-3 Chemical Structure| 633283-63-3

Structure of 633283-63-3

Chemical Structure| 633283-63-3

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Product Details of [ 633283-63-3 ]

CAS No. :633283-63-3
Formula : C14H20ClN3O2
M.W : 297.78
SMILES Code : O=C(N1CCN(C2=CC(Cl)=NC=C2)CC1)OC(C)(C)C
MDL No. :MFCD09952113

Safety of [ 633283-63-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H315-H318-H335
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 633283-63-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 633283-63-3 ]

[ 633283-63-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 26452-80-2 ]
  • [ 57260-71-6 ]
  • [ 936368-68-2 ]
  • [ 633283-63-3 ]
YieldReaction ConditionsOperation in experiment
22%; 51% With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 120.0℃; 2,4-Dichloropyridine (1.00 g, 6.7 mmol) and piperazine-1-carboxylic acid tert-butyl ester (1.64 g, 8.8 mmol) were suspended in DMF (10 ml) and iPr2NEt (2.30 ml, 14 mmol) was added. After stirring over night at 120 C. the reaction mixture was diluted with H2O and extracted with EtOAc. The organic layer was dried (Na2SO4) and the solvent was evaporated. The residue was purified by flash chromatography (SiO2 50 g, nHept/EtOAc 5 to 100%) to yield 1.02 g (51%) of product and 450 mg (22%) of the regioisomer as byproduct. Light yellow solid. m/z: 298.4 ([M+H]+).
 

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