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Chemical Structure| 62749-44-4 Chemical Structure| 62749-44-4

Structure of 62749-44-4

Chemical Structure| 62749-44-4

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Product Details of [ 62749-44-4 ]

CAS No. :62749-44-4
Formula : C11H11N3O
M.W : 201.22
SMILES Code : O=C1C(N)=CC(C2=CC=NC=C2)=CN1C

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Application In Synthesis of [ 62749-44-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 62749-44-4 ]

[ 62749-44-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 910543-72-5 ]
  • [ 1692-15-5 ]
  • [ 62749-44-4 ]
YieldReaction ConditionsOperation in experiment
46% With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); XPhos; In butan-1-ol; at 110℃; for 3h;Inert atmosphere; 4-Pyridyl boronic acid (73 mg, 0.591 mmol, 1.2 equivalents), 2-dicyclohexylphosphino-2,4,6-triisopropylbiphenyl (47 mg, 0.99 mmol, 0.2 equivalents), potassium phos-phate (315 mg, 1.478 mmol, 3 equivalents) and tris(dibenzylideneacetone) dipal-ladium(0) (23 mg, 0.025 mmol, 0.05 equivalents) were added to <strong>[910543-72-5]1-methyl-3-amino-5-bromopyridin-2-one</strong> (100 mg, 0.493 mmol, 1 equivalent) in butan-1-ol (5 mL) and the reaction mixture was heated to 110 C for 3 hours. The solution was then cooled and filtered through a pad of celite, which was washed with MeOH. The solution was concentrated and the residue taken up in MeOH and filtered through a SCX column and then purified by column chromatography (5% MeOH in CHCl3) to give a brown solid (45 mg, 46%).
  • 2
  • [ 153888-45-0 ]
  • [ 62749-44-4 ]
 

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