61533-68-4|2-Chloro-5-(2-methoxyethoxy)pyrimidine| Ambeed

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CAS No. :	61533-68-4
Formula :	C₇H₉ClN₂O₂
M.W :	188.61
SMILES Code :	COCCOC1=CN=C(Cl)N=C1
MDL No. :	MFCD26403410
Boiling Point :	No data available

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319
Precautionary Statements:	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Yield	Reaction Conditions	Operation in experiment
85%	With potassium carbonate; In N,N-dimethyl-formamide; at 50℃; for 16h;Inert atmosphere;	j0399j 2-Chloropyrimidin-5-ol (200 mg, 1.53 mmol), 1-bromo-2-methoxyethane (0.158 mL, 1.69 mmol) and potassium carbonate (423.5 mg 3.06 mmol) were suspended in anhydrous NN-dimethylformamicle (5 mL) and heated 10 50 °C in a nitrogen almosphere for 16 hours. The solvents were removed in vacuo and the residue was partitioned between ethyl acetate (50 mL) and water (30 mL), the aqueous was extracted with ethyl acetate (2 x 30 niL) and the conbilled organics washed with brine (20 mL), dried over anhydrous sodium sulfate, filtered and concentrated to give the title compound 244 mg (yield 85percent) as off-white translucent crystals. &i NMR (500 MHz, DMSO) 8.55 (s, 2F1), 4.37 ?4.21 (m, 2H), 3.78 ? 3.59 (m, 2H), 3.30 (s, 3H). Tr(METCRI278) = 1.36 mill, (Est) (M+Na)t 189.
	With potassium carbonate; In N,N-dimethyl-formamide; at 60℃; for 26h;	To a stirred solution of 2-chloropyrimidm-5-ol (Intermediate No.86 Step 2, 17.5 g, 134 mmol) in DMF (90 mL was added 2-bromoethyl methyl ether (17.6 mL, 1-87 mmol) followed by K2C03 (24.0 g, 174 mmol). The. resulting suspension was heated at 60 °C for 18 hr. In order to drive the reaction to completion, additional 2-bromoethyl methyl ether (16.0 mL, 170 mmol) and K2C03 (18.5 g, 134 mmol) were added, and- the heating was continued for approximately 8 hr. The reaction mixture was cooled and partitioned between 10percent aqueous sodium chloride (250 mL) and EtOAc (500 mL). The layers were separated and the organic layer was washed with 10percent aqueous sodium chloride (250 mL). The first aqueous layer was extracted with EtOAc (250 mL). The second aqueous layer was salted with solid NaCl, and extracted with EtOAc (250-mL). The combined organic layers were driecLover Na2S04, filtered, andconcentrated to a crude oil that was taken up into a minimal amount of DCM and purified by silica gel chromatography to afford 2-chIoro-5-(2-methoxyethoxy)pyrimidine as a white solid. LRMS (ESI) calc'd for C7H10C1N2O2 [M+Hf: 189. ; found 189.

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CAS No.: 61533-68-4

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CAS No.: 61533-68-4

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Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed