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Chemical Structure| 61309-99-7 Chemical Structure| 61309-99-7

Structure of 61309-99-7

Chemical Structure| 61309-99-7

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Product Details of [ 61309-99-7 ]

CAS No. :61309-99-7
Formula : C14H11NO
M.W : 209.24
SMILES Code : CC1=NC2=CC=C(C3=CC=CC=C3)C=C2O1

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Application In Synthesis of [ 61309-99-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 61309-99-7 ]

[ 61309-99-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 151230-42-1 ]
  • [ 98-80-6 ]
  • [ 61309-99-7 ]
YieldReaction ConditionsOperation in experiment
81% With potassium phosphate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 150.0℃; for 0.666667h;Inert atmosphere; Microwave irradiation; To a solution of Compound 24 (480 mg, 2.264 mmol) in 1,4-dioxane (7 mL) were added TETRAKIS(TRIPHENYLPHOSPHINE) PALLADIUM (0) (183 mg, 0.158 mmol), PHENYLBORONIC ACID (414 mg, 3.40 mmol) and 2M aqueous potassium phosphate solution (3.4 ml, 6.8 mmol) under nitrogen atmosphere at room temperature, then the reaction mixture was stirred at 150 C. for 40 minutes under microwave irradiation. To the reaction solution was added 1N hydrochloric acid, then the reaction solution was extracted with ethyl acetate. The extraction was washed with brine and dried over sodium sulfate. The solvent was removed under reduced pressure. The obtained residue was purified by column chromatography to give Compound 25 (385 mg, 81%).Compound 25; 1H-NMR (DMSO-d6) delta: 2.64 (s, 3H), 7.38 (dd, J=8.4, 2.0 Hz, 1H), 7.47-7.51 (m, 2H), 7.64 (d, J=2.0 Hz, 1H), 7.77-7.75 (m, 3H), 7.96 (s, 1H)
 

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