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Chemical Structure| 60081-99-4 Chemical Structure| 60081-99-4

Structure of 60081-99-4

Chemical Structure| 60081-99-4

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Product Details of [ 60081-99-4 ]

CAS No. :60081-99-4
Formula : C10H12N2
M.W : 160.22
SMILES Code : N#CC1=CC=C(N(C)C)C(C)=C1

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Application In Synthesis of [ 60081-99-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 60081-99-4 ]

[ 60081-99-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 124-40-3 ]
  • [ 185147-08-4 ]
  • [ 60081-99-4 ]
YieldReaction ConditionsOperation in experiment
100% With potassium carbonate; In dimethyl sulfoxide; at 60 - 85℃; Synthesis of 4-dimethylamino-3-methyl-benzonitrile (4.1)11.0 g (242 mmol) dimethylamine was piped into 100 ml dimethylsulphoxide up to the solubility limit, then 22.0 g (156 mmol) potassium carbonate and 10.0 g (74 mmol) <strong>[185147-08-4]4-fluoro-3-methyl-benzonitrile</strong> were added.The reaction mixture was stirred for 4 h at 60° C., then transferred into a large pressurised flask and another 9.0 g (198 mmol) dimethylamine were piped in.The reaction mixture was stirred overnight at 85° C.A further 10.0 g (220 mmol) dimethylamine were piped in and then the mixture was stirred for 4 h at 85° C. and overnight at 110° C.500 ml ice water was added to the reaction mixture, then it was extracted 3 times with 250 ml ethyl acetate, the org.phase was dried, filtered and the solvent was eliminated from the filtrate.Yield: 12.0 g (75 mmol=101percent of theory)Analysis: HPLC-MS (method D): Rt: 0.94 min, (M+H)+: 161
 

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