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Chemical Structure| 60042-05-9 Chemical Structure| 60042-05-9

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Chemical Structure| 60042-05-9

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Product Details of [ 60042-05-9 ]

CAS No. :60042-05-9
Formula : C13H8FNO
M.W : 213.21
SMILES Code : O=C1NC2=CC=CC=C2C3=C1C=C(F)C=C3

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Application In Synthesis of [ 60042-05-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 60042-05-9 ]

[ 60042-05-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 139911-28-7 ]
  • [ 191171-55-8 ]
  • [ 60042-05-9 ]
YieldReaction ConditionsOperation in experiment
65% With sodium carbonate; In ethanol; at 80.0℃; for 3.0h; Example 2a. 8-fluorophenanthridin-6-ol.A mixture of m<strong>[139911-28-7]ethyl 2-bromo-5-fluorobenzoate</strong> (0.250 g, 1.07 mmol), 2-(4,4,5,5-tetramethyl- l,3,2-dioxaborolan-2-yl)aniline (0.235 g, 1.07 mmol), palladium acetate (2.4 mg, 0.01 eq.), dicyclohexyl(2',6'-dimethoxybiphenyl-2-yl)phosphine (8.81 mg, 0.021 mmol), and sodium carbonate (0.114 g, 1.073 mmol) in ethanol (5.4 mL) was heated to 80 C for 3 h. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The resulting residue was triturated with hexane, and isolated by vacuum filtration, washed with water, and dried to provide the title compound (0.15 g, 65% yield) which was used without further purification
 

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