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Chemical Structure| 5814-06-2 Chemical Structure| 5814-06-2

Structure of 5814-06-2

Chemical Structure| 5814-06-2

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Product Details of [ 5814-06-2 ]

CAS No. :5814-06-2
Formula : C7H6Cl2N2O
M.W : 205.04
SMILES Code : O=C(NN)C1=CC=C(Cl)C=C1Cl
MDL No. :MFCD00025113
InChI Key :QOJQHOGSXXSMKX-UHFFFAOYSA-N
Pubchem ID :138596

Safety of [ 5814-06-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Application In Synthesis of [ 5814-06-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5814-06-2 ]

[ 5814-06-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 56882-52-1 ]
  • [ 5814-06-2 ]
YieldReaction ConditionsOperation in experiment
With hydrazine hydrate; In ethanol; for 6.5h;Reflux; General procedure: A mixture of substituted ethyl benzoate (12a-g) (0.1M) and hydrazine hydrate (0.3M) was heated under reflux for 30min. Ethanol (20mL) was added to the refluxing mixture as a solvent in order to homogenize the solution, the resulting mixture was further allowed for 6h. Excess of ethanol was distilled out and the content was allowed to cool. The crystals formed were filtered and washed thoroughly with water and dried.
With hydrazine hydrate; In ethanol;Reflux; General procedure: To a stirred solution of ethyl benzoate (3 mmol) derivatives in ethanol was added hydrazine-hydrate (5.44 mmol) and refluxed for 6-12 h. The reaction mixture was diluted with ethyl acetate followed by water. The organic layer was dried over sodium sulphate, filtered and evaporated to obtain the respective benzohydrazide derivatives (4a-m)15,16. The yields of the products varied from 80-85 %.
With hydrazine hydrate; In ethanol; at 20℃; for 3h; General procedure: A mixture of substituted ethyl benzoate 2 (10 mmol) and hydrazinehydrate (20 mmol) in ethanol was stirred at room temperaturefor 3 h and then filtered. The crude product recrystallizedfrom absolute alcohol to give 3a-l, which were used directly forthe next step. Under this same condition, the intermediate compounds 8a-d were also prepared.
With hydrazine hydrate; In ethanol; for 5h;Reflux; General procedure: 5mL of hydrazine monohydrate (80%) was added to a solution of intermediate 3 (5mmol) in ethanol (5mL). The reaction mixture was maintained under reflux for 5h. was then concentrated under reduced pressure and the resulting solid was collected by filtration, washed with cold water and dried to give the desired intermediate 4 as a white solid.
With hydrazine hydrate; In methanol;Reflux; General procedure: The ethyl esters (0.15 mol; 2a-o) were taken in 250 mL round bottom flask.About 30 mL of methanol was added to the flask and homogenized by stirringat room temperature. Hydrazine hydrate (80%; 0.15 mol) was introduced to theflask drop wise and the reaction apparatus was refluxed for 5-6 hrs. Reactionprogress was confirmed by thin layer chromatography. n-Hexane and ethylacetate (3:2). At the end of reaction, excess of solvent was evaporated andresidue was poured into the ice cold water. Precipitates of acid hydrazides werefiltered, washed with water and dried. Re-crystallization of acid hydrazides wasperformed by using methanol.
With hydrazine; In ethanol;Reflux; General procedure: The synthesized aryl/aralkyl esters (IIa-n)(3.5 mL) were diluted in 250 mL ethanol followed byaddition of 4.8 mL 80% hydrazine. Refluxing wascontinued for 4-6 h. After monitoring by TLC, icecold distilled H2O was poured to acquire the precipitatesof (IIIa-n), which were filtered and washed offwith cold distilled H2O [18, 19].
With hydrazine hydrate; In ethanol;Reflux; General procedure: Ethyl ester (Va-n) (0.04 mol) was refluxed with 80% N2H4 · H2O(7.2 mL) for 3-4 h in 20 mL EtOH in a round-bottom flask (100 mL). The reaction was monitored by TLC. At completion, excess ice-cold distilled water (60 mL) was added to get the precipitate, which was filtered, washed with distilled water, and dried to acquire title compounds (VIa-n) [18, 19].

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