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Chemical Structure| 56048-54-5 Chemical Structure| 56048-54-5

Structure of 56048-54-5

Chemical Structure| 56048-54-5

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Product Details of [ 56048-54-5 ]

CAS No. :56048-54-5
Formula : C14H11NOS
M.W : 241.31
SMILES Code : OC1=CC(C)=CC=C1C2=NC3=CC=CC=C3S2
MDL No. :MFCD00043783

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Application In Synthesis of [ 56048-54-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 56048-54-5 ]

[ 56048-54-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 16112-21-3 ]
  • [ 56048-54-5 ]
YieldReaction ConditionsOperation in experiment
85% With [bis(acetoxy)iodo]benzene; palladium diacetate; acetic acid; at 110℃; for 4h; General procedure: An oven-dried flask was charged with Pd(OAc)2 (0.05 mmol), diacetoxyiodobenzene (DIB) (1.0 mmol), substituted 2-phenylbenzo[d]thiazole (1-18) (1.0 mmol), and acetic acid (2 mL). Then the reaction vessel was kept in an oil bath preheated to 110 C and allowed to stir for the stipulated period of time. The progress of the reaction was monitored by TLC. During this period complete disappearance of substituted 2-phenylbenzo[d]thiazole was observed with the appearance of one major product having higher Rf [in some cases (1b, 4b, 16b, 15c, 18c)] another product was also observed having lower Rf with respect to the substrate. The reaction mixture was then cooled and admixed with water (5 mL). The product was extracted with ethyl acetate (2×10 mL) and the combined organic layer was washed with saturated sodium bicarbonate (NaHCO3) solution. Organic layer was dried over anhydrous sodium sulfate (Na2SO4) and evaporated under reduced pressure. The crude product so obtained was further purified through silica gel column chromatography (EtOAc/hexane) to yield the pure product. The identity and purity of the products were confirmed by spectroscopic analysis.
 

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