55242-83-6|2-(1,2-Oxazol-3-yl)acetonitrile| Ambeed

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CAS No. :	55242-83-6
Formula :	C₅H₄N₂O
M.W :	108.10
SMILES Code :	N#CCC1=NOC=C1
MDL No. :	MFCD16629913

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H312-H315-H319-H332-H335
Precautionary Statements:	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Yield	Reaction Conditions	Operation in experiment
88.8%	In dimethyl sulfoxide; at 40℃;	In a three-necked flask, 200 mL of dimethyl sulfoxide and 30.0 g of 3-chloromethylisoxazole were added, and 21.5 g of copper cyanide was added.After heating to 40C, after completion of the reaction, 500 mL of water was added and the mixture was extracted with methylene chloride (100 mL x 3), and the organic phases were combined.Washed with saturated sodium bicarbonate, saturated brine, dried over anhydrous sodium sulfate,Concentration gave 24.5 g (88.8%) of 3-isoxazole acetonitrile.
	In dimethyl sulfoxide; at 30℃;	Add dimethyl sulfoxide and 3-chloromethylisoxazole to a three-necked flask, add cuprous cyanide, and heat to 30 C.After the reaction is completed, water is added, and the organic phase is extracted with dichloromethane, and washed with saturated sodium hydrogen carbonate.Wash with saturated brine and dry over anhydrous sodium sulfate.Concentrated to give 3-isoxazolylacetonitrile.

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P411 + P235	Keep cool.
Disposal
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P501	Dispose of contents/container to ...
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CAS No.: 55242-83-6

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CAS No.: 55242-83-6

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[ 55242-83-6 ] Synthesis Path-Downstream 1~2

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed