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Chemical Structure| 545424-53-1 Chemical Structure| 545424-53-1

Structure of 545424-53-1

Chemical Structure| 545424-53-1

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Product Details of [ 545424-53-1 ]

CAS No. :545424-53-1
Formula : C11H10N2O
M.W : 186.21
SMILES Code : O=C/C=C/C1=NC2=CC=CC=C2N1C

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Application In Synthesis of [ 545424-53-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 545424-53-1 ]

[ 545424-53-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3012-80-4 ]
  • [ 2136-75-6 ]
  • [ 545424-53-1 ]
YieldReaction ConditionsOperation in experiment
46% In N,N-dimethyl-formamide; at 25℃; General procedure: The reaction mixture of aldehyde (0.5mmol) and 2-(triphenylphosphoranylidene)acetaldehyde (0.51mmol) in DMF (0.5mL) was stirred for 1-4days and detected with TLC. The reaction mixture was extracted with dichloromethane (10mL×3). The combined organic extracts were rinsed with brine (5mL×3) and dried over anhydrous magnesium sulfate, and the volatile components were evaporated under vacuum to give the crude product, which was subjected to the PTLC purification using hexanes/ethyl acetate (1/1, v/v) as eluent to give the respective product. All intermediates were directly used for the next step reaction after confirming with their 1H NMR data. The 1H NMR data for the sixteen known (E)-3-aryl-2-propenals (33, 34, 36, 37, 39-46, 48, 49, 56, 57) are in consistent with those reported in the literature.
 

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