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Chemical Structure| 5353-90-2 Chemical Structure| 5353-90-2

Structure of 5353-90-2

Chemical Structure| 5353-90-2

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Product Details of [ 5353-90-2 ]

CAS No. :5353-90-2
Formula : C16H13N
M.W : 219.28
SMILES Code : CC1=C2N=C(C=CC2=CC=C1)C1=CC=CC=C1
MDL No. :MFCD22376729

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Application In Synthesis of [ 5353-90-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5353-90-2 ]

[ 5353-90-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 57772-50-6 ]
  • [ 536-74-3 ]
  • [ 5353-90-2 ]
YieldReaction ConditionsOperation in experiment
74% With trifluorormethanesulfonic acid; silver trifluoromethanesulfonate; lithium bromide; In water; toluene; at 40℃; for 8h;Green chemistry; General procedure: A test tube (25 mL) wascharged with 2-aminobenzyl alcohol 1 (0.5 mmol, 1equiv), alkynes 2 (0.75 mmol, 1.5 equiv), AgOTf (0.025 mmol, 5 mol %), HOTf (0.05mmol, 10 mol%), LiBr (0.05 mmol, 10mol%), H2O (0.2 mL), and toluene (3 mL) were added. Themixture was stirred at 40 oC in air for 8 hours, the reaction wascooled down to room temperature, the mixture was quenched by sat. aq. NaHCO3,and diluted with 10 mL dichloromethane and washed with 10 mL H2O.The aqueous layer was extracted twice with dichloromethane (10 mL) and thecombined organic phase was dried over Na2SO4. Afterevaporation of the solvents, the residue was purified by silica gelchromatography (hexane/AcOEt = 30:1).
  • 2
  • [ 57772-50-6 ]
  • [ 98-86-2 ]
  • [ 5353-90-2 ]
YieldReaction ConditionsOperation in experiment
83% With [(eta5-C5Me5)Ir(6,6'-dihydroxy-2,2'-bipyridine)(H2O)]OTf2; potassium hydroxide; In water; for 12h;Reflux; Green chemistry; Acetophenone (144 mg, 1.2 mmol),[Cp * Ir (6,6 '- (OH) 2bpy) (H2O)] [OTf] 2 (8.3 mg,0.01 mmol, 1 mol%), potassium hydroxide (56 mg, 1.0 mmol, 1.0 equiv.),2-Amino-3-methylbenzyl alcohol(137 mg, 1.0 mmol) and water (1 mL) were sequentially added to a 5 mL round bottom flask.The reaction mixture was refluxed in air for 12 hours and then cooled to room temperature.Extraction with ethyl acetate, removal of the solvent by rotary evaporation and purification of the target compound by column chromatography (developing solvent: petroleum ether / ethyl acetate) yielded 83%
 

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