CAS No. : | 5281-18-5 | MDL No. : | MFCD00156178 |
Formula : | C7H8N2 | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 120.15 | Pubchem ID : | - |
Synonyms : |
Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P264-P270-P280-P301+P312+P330-P305+P351+P338+P310-P501 | UN#: | 3267 |
Hazard Statements: | H302-H318 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67%; 55% | With hydrazine hydrate; In neat (no solvent); for 6h;Reflux; | General procedure: Amixture ofDHPMs a-h(0.01mol) and excess hydrazine hydrate (5 mL) was heatedunder reflux for 6 h. The reaction mixture was allowed tocool and poured on crushed ice.The obtained solid producta-d was filtered, crystallized from ethanol, and finallydried.The evaporation of the filtrate gave solid residue whichupon fractional crystallization from water gave the pyrazole and urea (a)/thiourea (b), respectively. 2.4.1. 3-Methyl-1H-pyrazol-5-ol (13). Yield: 42-55% (for a-h); m.p. 221-223 C (Lit. [49] m.p. 220-222 C); 1H-NMR(DMSO-6) δ (ppm): 2.47 (s, 3H, -CH3), 6.83 (s, 1H, Ar-H),10.07 (s, 1H, OH), 12.10 (s, 1H,NH). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62%; 55% | With hydrazine hydrate; In neat (no solvent); for 6h;Reflux; | General procedure: Amixture ofDHPMs a-h(0.01mol) and excess hydrazine hydrate (5 mL) was heatedunder reflux for 6 h. The reaction mixture was allowed tocool and poured on crushed ice.The obtained solid producta-d was filtered, crystallized from ethanol, and finallydried.The evaporation of the filtrate gave solid residue whichupon fractional crystallization from water gave the pyrazole and urea (a)/thiourea (b), respectively. 2.4.1. 3-Methyl-1H-pyrazol-5-ol (13). Yield: 42-55% (for a-h); m.p. 221-223 C (Lit. [49] m.p. 220-222 C); 1H-NMR(DMSO-6) δ (ppm): 2.47 (s, 3H, -CH3), 6.83 (s, 1H, Ar-H),10.07 (s, 1H, OH), 12.10 (s, 1H,NH). |
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