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Chemical Structure| 52499-04-4 Chemical Structure| 52499-04-4

Structure of 52499-04-4

Chemical Structure| 52499-04-4

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Product Details of [ 52499-04-4 ]

CAS No. :52499-04-4
Formula : C4H5N3OS
M.W : 143.17
SMILES Code : O=C(C1=CN=C(N)S1)N
MDL No. :MFCD08444315

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Application In Synthesis of [ 52499-04-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 52499-04-4 ]

[ 52499-04-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6633-61-0 ]
  • [ 52499-04-4 ]
YieldReaction ConditionsOperation in experiment
49% With ammonia; In water; at 50℃; for 72h; Example 12 (E)-2-[2-(3-Chloro-4-methanesulfonyl-phenyl)-2-cyclohexyloxyimino-acetylamino]-thiazole-5-carboxylic acid amide 2-Amino-thiazole-5-carboxylic acid methyl ester (333 mg, 2.11 mmol) and a solution of concentrated ammonium hydroxide (4.2 mL) were combined and heated to 50 C. After stirring 72 h, the mixture was cooled, filtered and the filtrate was concentrated in vacuo to half the original volume. The precipitate was collected by filtration in vacuo and washed with water. Drying in vacuo afforded the desired product, 2-amino-thiazole-5-carboxylic acid amide (148 mg, 49%) as a tan solid that was used without further purification: LC-MS (ESI) m/e calcd for C4H5N3OS [M+] 103.02, found 286.9 [2M+H+]; H1-NMR (400 MHz, CD3OD) delta=7.59 (1H, s).
 

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