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Chemical Structure| 51786-82-4 Chemical Structure| 51786-82-4

Structure of 51786-82-4

Chemical Structure| 51786-82-4

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Product Details of [ 51786-82-4 ]

CAS No. :51786-82-4
Formula : C7H7N3O
M.W : 149.15
SMILES Code : NC1=C2C(OC=C2C)=NC=N1
MDL No. :MFCD12755955

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Application In Synthesis of [ 51786-82-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 51786-82-4 ]

[ 51786-82-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5117-87-3 ]
  • [ 6313-33-3 ]
  • [ 51786-82-4 ]
YieldReaction ConditionsOperation in experiment
5-methylfuro[2,3-d]pyrimidin-4-amine (5) Sodium metal (2.3 g; 0.1M) was added cautiously to stirred anhydrous Ethanol (5.8 mL, 0.1M) over 10 min at room temperature. After stirring the resulting slurry for additional 5 min, 4 (8.05 gm, 0.1M) was added. The slurry was stirred at room temperature for 30 min after which solution of 3 (13 g crude; ?0.1M) in anhydrous ethanol (200 mL) was added. The mixture was heated at reflux for 8 h. After cooling the reaction mixture to room temperature, silica gel (25 g) was added and solvents evaporated under reduced pressure to obtain a plug. Purification was done by flash chromatography using 1% methanol in chloroform. The fractions corresponding to the product spot were pooled and evaporated under reduced pressure to obtain 5 (5.3 g, 35%) as lustrous pink crystals. TLC Rf0.29 (CHCl3:MeOH, 10:1); mp 240.2-242.5 C.; 1H-NMR (300 MHz) (DMSO-d6): delta 2.28 (s, 3H, CH3); 7.018 (br, 2H, NH2, exch), 7.528 (s, 1H, C6-CH), 8.12 (s, 1H, C2-CH) Anal. Calcd for C7H7N3O: C, 56.37; H, 4.73; N, 28.17; Found: C, 56.48; H, 4.74; N, 28.17.
 

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