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Chemical Structure| 50874-07-2 Chemical Structure| 50874-07-2

Structure of 50874-07-2

Chemical Structure| 50874-07-2

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Product Details of [ 50874-07-2 ]

CAS No. :50874-07-2
Formula : C14H18O5
M.W : 266.29
SMILES Code : O=C(OCC)C(C1=CC=CC(OC)=C1)C(OCC)=O
MDL No. :MFCD17969564

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Application In Synthesis of [ 50874-07-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 50874-07-2 ]

[ 50874-07-2 ] Synthesis Path-Downstream   1~3

  • 2
  • [ 35553-92-5 ]
  • [ 623-49-4 ]
  • [ 50874-07-2 ]
  • 3
  • [ 19213-72-0 ]
  • [ 35553-92-5 ]
  • [ 50874-07-2 ]
YieldReaction ConditionsOperation in experiment
76% General procedure: To a stirred solution of phenyl acetic acid ethyl ester 1a (1 g, 6.09 mmol) in THF (10 mL) was added LiHMDS (9.1 ml, 1 M sol. in THF, 7.31 mmol) at -78 C and the reaction mixture was stirred at this temperature for 30 min. Ethyl-1-imidazole carboxylate 2 (1.2 g, 9.146 mmol) in dry THF (3 ml) was added drop wise to the reaction mixture at -78 C and stirred at rt for 3 h. The reaction mixture was quenched with saturated ammonium chloride solution and extracted with ethyl acetate. The combined organic layer was washed with water, saturated brine solution, and dried over Na2SO4. The solvent was evaporated under reduced pressure and the crude product was chromatographed on a silica gel column. Elution with 4% ethyl acetate/pet ether gave the pure compound 3a (1.1 g, 81% yield) as a colorless liquid.
 

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