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Chemical Structure| 50717-82-3 Chemical Structure| 50717-82-3

Structure of 50717-82-3

Chemical Structure| 50717-82-3

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Product Details of [ 50717-82-3 ]

CAS No. :50717-82-3
Formula : C5H9NO
M.W : 99.13
SMILES Code : O=C1CNCCC1
MDL No. :MFCD06738686

Safety of [ 50717-82-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P260-P264-P280-P305+P351+P338-P405-P501
Class:8
UN#:2735
Packing Group:

Application In Synthesis of [ 50717-82-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 50717-82-3 ]

[ 50717-82-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 50606-58-1 ]
  • [ 50717-82-3 ]
YieldReaction ConditionsOperation in experiment
With hydrogen;palladium 10% on activated carbon; In methanol; under 2844.39 Torr; for 16h; To a stirred solution of N-benzyl-3-piperidone hydrochloride hydrate (4.2 g, 18.6 mmol) and 10% palladium on carbon (0.8 g) in degassed methanol (200 mL) was added hydrogen gas to 55 psi. The reaction mixture was stirred for 16 hr and then filtered through a pad of celite. The celite was washed with methanol (200 mL). The filtrates were combined and concentrated in vacuo to a colorless oil. The oil was dissolved in tetrahydrofuran (200 mL) and then treated with di-t-butyl-dicarbonate (5.27 g, 24.1 mmol) and a saturated aqueous sodium bicarbonate solution (50 mL). The reaction was stirred for 4 hr and then concentrated in vacuo to a white solid. The solid was partitioned between ethyl acetate and 1N hydrochloric acid. The organic layer was separated, washed with 1N sodium hydroxide and brine, dried over Na2SO4, and evaporated in vacuo to a colorless oil. The oil was purified by flash chromatography (silica gel, hexane:ethyl acetate 3:1) to yield 2.93 g of a colorless oil. 1H NMR (300 MHz, CDCl3) delta 3.99 (s, 2H), 3.58 (t, J=6, 2H), 2.46 (t, J=6, 2H), 1.97 (p, J=6, 2H), 1.45 (s, 9H).
 

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