4945-46-4|6-(Piperidin-1-yl)pyridin-2-amine| Ambeed

Yield	Reaction Conditions	Operation in experiment
94%	at 205℃; for 0.5h;Microwave irradiation;	A suspension of <strong>[1597-32-6]6-fluoropyridin-2-amine</strong> (500 mg, 4.4 mmol), piperidine (1.4 mL, 14.1 mmol) in water (0.5 mL) was heated to 205 C. in a microwave oven for 30 minutes. The reaction mixture was purified by chromatography (silica gel, 200-300 mesh, petroleum ether:ethyl acetate=3:1) to give 6-(piperidin-1-yl)pyridin-2-amine (740 mg, 94%) as a light yellow oil. LC-MS: [M+H]+, 178.1, tR=0.974 min.
94%	In water; at 205℃; for 0.5h;Microwave irradiation;	A suspension of <strong>[1597-32-6]6-fluoropyridin-2-amine</strong> (500 mg, 4.4 mmol), piperidine (1.4 mL , 14.1 mmol) in water (0.5 mL) was heated to 205 C in a microwave oven for 30 minutes. The reaction mixture was purified by chromatography (silica gel, 200 - 300 mesh, petroleum ether : ethyl acetate = 3 : 1) to give 6-(piperidin-l-yl)pyridin-2-amine(740 mg, 94 %) as a light yellow oil. LC-MS : [M+H]+, 178.1 , tR = 0.974min.

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H420	Harms public health and the environment by destroying ozone in the upper atmosphere

6-(Piperidin-1-yl)pyridin-2-amine

CAS No.: 4945-46-4

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[ 4945-46-4 ] Synthesis Path-Downstream 1~1

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