Home Cart Sign in  
Chemical Structure| 492431-12-6 Chemical Structure| 492431-12-6

Structure of 492431-12-6

Chemical Structure| 492431-12-6

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 492431-12-6 ]

CAS No. :492431-12-6
Formula : C13H20N4O2
M.W : 264.32
SMILES Code : O=C(N1CCN(C2=NN=CC=C2)CC1)OC(C)(C)C
MDL No. :MFCD19689624
InChI Key :KNCRBGIXAOVMQM-UHFFFAOYSA-N
Pubchem ID :21925497

Safety of [ 492431-12-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Application In Synthesis of [ 492431-12-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 492431-12-6 ]

[ 492431-12-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 492431-11-5 ]
  • [ 492431-12-6 ]
YieldReaction ConditionsOperation in experiment
With hydrogen;palladium 10% on activated carbon; In DMF (N,N-dimethyl-formamide); ethanol; at 20℃; under 760.051 Torr; A mixture of 10.5 g of the compound obtained in the preceding step and 2.5 g of 10% palladium on carbon in 30 ml of DMF and 250 ml of EtOH is hydrogenated at AT under atmospheric pressure overnight. The catalyst is filtered off and the filtrate is concentrated under vacuum. The residue is chromatographed on silica gel, eluting with a DCM/MeOH (97/3 to 90/10; v/v) mixture. This gives 9.1 g of the expected product, which is used as it is.
With hydrogen;palladium 10% on activated carbon; In DMF (N,N-dimethyl-formamide); ethanol; at 20℃; under 760.051 Torr; A mixture of 10.5 g of the compound obtained in the preceding step and 2.5 g of 10% palladium-on-charcoal in 30 ml of DMF and 250 ml of EtOH is hydrogenated overnight at RT and atmospheric pressure. The catalyst is filtered off and the filtrate is concentrated under vacuum. The residue is chromatographed on silica gel, eluting with a DCM/MeOH mixture of from (97/3; v/v) to (90/10; v/v). 9.1 g of the expected product are obtained, and are used without further purification.
  • 2
  • [ 1120-95-2 ]
  • [ 57260-71-6 ]
  • [ 492431-12-6 ]
YieldReaction ConditionsOperation in experiment
31% With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 120℃; for 16h; A mixture of <strong>[1120-95-2]3-<strong>[1120-95-2]chloropyridazine</strong></strong> (1 g, 8.73 mmol), tert-butyl piperazine-1-carboxylate(1.626 g, 8.73 mmol), and K2C03 (2.413 g, 17.46 mmol) in NMP (10 mL) was stirred at 120 °C for 16 h. The mixture was purified by chromatography (silica, EtOAc/PE =1/20) to afford tertbutyl 4-(pyridazin-3-yl)piperazine-1-carboxylate (709 mg, 2.68 mmol, 31percent) as a yellow oil. ESIMS (EI+, m/z): 265.4 [M+H]t
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 492431-12-6 ]

Amides

Chemical Structure| 1420898-69-6

A482865 [1420898-69-6]

tert-Butyl 4-(6-methylpyridazin-3-yl)piperazine-1-carboxylate

Similarity: 0.91

Chemical Structure| 947498-81-9

A894654 [947498-81-9]

tert-Butyl 4-(1H-indazol-3-yl)piperazine-1-carboxylate

Similarity: 0.88

Chemical Structure| 492431-11-5

A181819 [492431-11-5]

1-Boc-4-(6-Chloropyridazin-3-yl)piperazine

Similarity: 0.86

Chemical Structure| 1708269-17-3

A861343 [1708269-17-3]

tert-Butyl 4-(6-ethynylpyridazin-3-yl)piperazine-1-carboxylate

Similarity: 0.85

Chemical Structure| 1289385-71-2

A126016 [1289385-71-2]

tert-Butyl 4-(6-chloropyridazin-3-yl)-3-methylpiperazine-1-carboxylate

Similarity: 0.82

Related Parent Nucleus of
[ 492431-12-6 ]

Piperazines

Chemical Structure| 1420898-69-6

A482865 [1420898-69-6]

tert-Butyl 4-(6-methylpyridazin-3-yl)piperazine-1-carboxylate

Similarity: 0.91

Chemical Structure| 947498-81-9

A894654 [947498-81-9]

tert-Butyl 4-(1H-indazol-3-yl)piperazine-1-carboxylate

Similarity: 0.88

Chemical Structure| 492431-11-5

A181819 [492431-11-5]

1-Boc-4-(6-Chloropyridazin-3-yl)piperazine

Similarity: 0.86

Chemical Structure| 1708269-17-3

A861343 [1708269-17-3]

tert-Butyl 4-(6-ethynylpyridazin-3-yl)piperazine-1-carboxylate

Similarity: 0.85

Chemical Structure| 1289385-71-2

A126016 [1289385-71-2]

tert-Butyl 4-(6-chloropyridazin-3-yl)-3-methylpiperazine-1-carboxylate

Similarity: 0.82

Pyridazines

Chemical Structure| 1420898-69-6

A482865 [1420898-69-6]

tert-Butyl 4-(6-methylpyridazin-3-yl)piperazine-1-carboxylate

Similarity: 0.91

Chemical Structure| 492431-11-5

A181819 [492431-11-5]

1-Boc-4-(6-Chloropyridazin-3-yl)piperazine

Similarity: 0.86

Chemical Structure| 1708269-17-3

A861343 [1708269-17-3]

tert-Butyl 4-(6-ethynylpyridazin-3-yl)piperazine-1-carboxylate

Similarity: 0.85

Chemical Structure| 1261233-63-9

A722453 [1261233-63-9]

tert-Butyl 4-(6-chloropyridazin-3-yl)-2-methylpiperazine-1-carboxylate

Similarity: 0.82

Chemical Structure| 1289385-71-2

A126016 [1289385-71-2]

tert-Butyl 4-(6-chloropyridazin-3-yl)-3-methylpiperazine-1-carboxylate

Similarity: 0.82