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Chemical Structure| 478946-80-4 Chemical Structure| 478946-80-4

Structure of 478946-80-4

Chemical Structure| 478946-80-4

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Product Details of [ 478946-80-4 ]

CAS No. :478946-80-4
Formula : C7H7BrClNO
M.W : 236.49
SMILES Code : COC1=CC(CBr)=CC(Cl)=N1

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Application In Synthesis of [ 478946-80-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 478946-80-4 ]

[ 478946-80-4 ] Synthesis Path-Downstream   1~3

  • 3
  • [ 603-35-0 ]
  • [ 193001-91-1 ]
  • [ 478946-80-4 ]
YieldReaction ConditionsOperation in experiment
34% To a stirred ICEBATH-COOLED solution of triphenylphosphine (1.36 g, 5.19 mmol) in DCM (75 mL) was added bromine (0.83 g, 5.19 mmol) dropwise. Stirring of the resulting colorless solution was continued for 30 min after which time the ice-bath was removed. Example 18 (0.75 g, 4.32 mmol) was added portion-wise and the reaction mixture was stirred for another 2 h. DCM (75 mL) was added and the organic phase was washed with water (100 mL) and brine (100 mL). Drying (NA2S04) of the DCM-layer and evaporation in vacuo gave A solid residue that was purified by flash column chromatography over silica gel eluting with DCM giving 350 mg (34 %) of a white solid. 'H NMR (400 MHz, CDCL3) 8 3.93 (s, 3H) 4.27 (s, 2H) 6.64 (s, 1H) 6.92 (s, 1H).
 

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