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Chemical Structure| 477585-30-1 Chemical Structure| 477585-30-1

Structure of 477585-30-1

Chemical Structure| 477585-30-1

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Product Details of [ 477585-30-1 ]

CAS No. :477585-30-1
Formula : C10H17NO3
M.W : 199.25
SMILES Code : O=C(OC(C)(C)C)NC1C(CCC1)=O
MDL No. :MFCD09751874

Safety of [ 477585-30-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 477585-30-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 477585-30-1 ]

[ 477585-30-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 454170-16-2 ]
  • [ 477585-30-1 ]
YieldReaction ConditionsOperation in experiment
Intermediate IV: 2,2-difluorocyclopentanaminium chloride; DMSO (1.92 mL, 6eq) in CH2Cl2 (2 mL) was added dropwise at -78 0C to a stirred solution of oxalyl chloride (1.16 mL, 3 eq) in CH2Cl2 (11 mL) under N2 protection. After stirring for 10 min, compound IVA (0.905 g, 0.00450 mol) in CH2Cl2 (3 mL) was added dropwise. The reaction mixture was stirred at -78 0C for 6 hours. TEA (3.76 mL, 6 eq) was added dropwise at -78 0C. The reaction mixture was extracted with saturated aqueous NaHCO3 /EtOAc twice, aqueous NaH2PO4 (pH=4) solution / EtOAc twice, washed with brine twice, dried with MgSO4 and concentrated to afford crude compound IVB (1.25 g). Purification by Combiflash chromatography (80 g silica gel, 8% EtOAc/Hexanes) afforded compound IVB. EPO <DP n="31"/>EI-MS m/z: 100 (M -C5H8O2 + H)+.
 

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Technical Information

• Acyl Group Substitution • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bouveault-Blanc Reduction • Bucherer-Bergs Reaction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Catalytic Hydrogenation • Chan-Lam Coupling Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Ester Cleavage • Fischer Indole Synthesis • Grignard Reaction • Halogenation • Heat of Combustion • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Lawesson's Reagent • Leuckart-Wallach Reaction • Mannich Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Amines • Reactions with Organometallic Reagents • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Specialized Acylation Reagents-Vilsmeier Reagent • Stobbe Condensation • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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