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Chemical Structure| 46276-24-8 Chemical Structure| 46276-24-8

Structure of 46276-24-8

Chemical Structure| 46276-24-8

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Product Details of [ 46276-24-8 ]

CAS No. :46276-24-8
Formula : C11H11N3
M.W : 185.23
SMILES Code : N#CC1=CC2=C(NC=C2CCN)C=C1
MDL No. :MFCD02683927

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Application In Synthesis of [ 46276-24-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 46276-24-8 ]

[ 46276-24-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 29882-07-3 ]
  • [ 2863-98-1 ]
  • [ 46276-24-8 ]
  • 2
  • [ 29882-07-3 ]
  • [ 17672-27-4 ]
  • [ 46276-24-8 ]
YieldReaction ConditionsOperation in experiment
23 g (35%) In methanol; ethanol; water; 2. 2-[5-Cyano-1H-indol-3-yl]ethylamine. Hydrochloride. To a stirred suspension of 4-cyanophenylhydrazine (50 g) in a mixture of ethanol and water (5:1; 21) was added 4-chlorobutanal dimethylacetal (45 g) and the resulting mixture was refluxed for 18 hours. Solvents were removed under vacuum and the residue was azeotroped with toluene to give a brown solid. Crystallisation of this crude material from methanol (150 ml) gave 23 g (35percent) of the title compound as a yellow solid; mp 270°-274° C.; 1 H NMR (250MHz, D6 -DMSO) delta 11.60 (1H, br s, indole N-H), 8.17 (1H, d, J=1.1Hz, Ar--H), 7.97 (3H br s, -N+ H3), 7.54 (1H, d, J=8 5Hz, Ar--H), 7.46 (1H, s, Ar--H), 7.44 (1H, dd, J=8.5 and 1.1Hz, Ar--H), 3.05 (4H, br s, --CH2 CH2 N--); m/z (CI) 184 (M+ -1).
 

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