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Chemical Structure| 454678-87-6 Chemical Structure| 454678-87-6

Structure of 454678-87-6

Chemical Structure| 454678-87-6

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Product Details of [ 454678-87-6 ]

CAS No. :454678-87-6
Formula : C10H12O
M.W : 148.20
SMILES Code : OCC1=CC=C(C2CC2)C=C1
MDL No. :MFCD06802675
InChI Key :OUUVDKAYACQKRO-UHFFFAOYSA-N
Pubchem ID :22135711

Safety of [ 454678-87-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 454678-87-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 454678-87-6 ]

[ 454678-87-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1798-82-9 ]
  • [ 454678-87-6 ]
YieldReaction ConditionsOperation in experiment
88% With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20℃; for 3h;Inert atmosphere; [00202] To a solution of 85 (100 mg, 0.617 mmol) in anhydrous THF (4 mL) was added LiA1H4 (70 mg, 1.850 mmol) in portions at 0 C under N2. The mixture was stirred at rt for 3h. The mixture was quenched successively with water (0.07 mL) and 10% aqueous NaOH solution (0.07 mL) at 0 C. The mixture was filtered and the filtrate was concentrated under reduced pressure. Water (15 mL) and ethyl acetate (15 mL) were added to the mixture. After partition, the aqueous layer was extracted with ethyl acetate (3 X 15 mL). The combined organic layers were washed with brine (25 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by preparative TLC with petroleum ether / ethyl acetate 5/1 to afford 86 (80 mg, 88%) as a colorless oil. ?H NMR (CDC13): 5 7.28 (d, J= 8.0 Hz, 2H), 7.10 (d, J= 8.0 Hz, 2H), 4.66 (s, 2H), 1.96-1.91 (m, 1H), 1.0 1-0.97 (m, 2H), 0.73-0.7 1 (m, 2H).
 

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