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[ CAS No. 4506-66-5 ]

{[proInfo.proName]} (Synonyms:FAK Inhibitor Y15; FAK Inhibitor 14) ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 4506-66-5
Chemical Structure| 4506-66-5
Structure of 4506-66-5 * Storage: {[proInfo.prStorage]}

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Product Details of [ 4506-66-5 ]

CAS No. :4506-66-5 MDL No. :MFCD00012970
Formula : C6H14Cl4N4 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :284.01 g/mol Pubchem ID :78260
Synonyms :

1. FAK Inhibitor 14; Y 15; Y-15

Safety of [ 4506-66-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 4506-66-5 ]

  • Upstream synthesis route of [ 4506-66-5 ]
  • Downstream synthetic route of [ 4506-66-5 ]

[ 4506-66-5 ] Synthesis Path-Upstream   1~3

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YieldReaction ConditionsOperation in experiment
81%
Stage #1: With tin; Degussa F101 catalyst; hydrogen In ethanol at 80.5℃; for 2 h; Autoclave; Inert atmosphere
Stage #2: With hydrogenchloride In ethanol; water at 15℃;
1,2,4,5-tetraminobenzene and its mineral and organic acid salts are susceptible to oxidation and should be handled in an inert atmosphere. To a 2 gallon autoclave was added 480 g of 1,5-diamino-2,4-dinitrobenzene, 5.5 g of T\tin powder, and 9.6 g of Degussa F101 Pt/C catalyst. The clave was then sealed, purged with nitrogen, and had added to it 2000 mL of nitrogen sparged ethanol. The clave was heated to 70° C. and pressurized to 300 psi with hydrogen and then kept at 80.5° C. and 300 psi for 2 h. After 2 h, the claves contents were pushed through a solids filter and into a precipitation vessel where they were cooled to 15° C. and the product precipitated with the addition 1400 mL of 12.1M HCl. The precipitated solids were collected, washed with 12.1 M HCl and ethanol, and partially dried on the filter at 40° C. with nitrogen and vacuum. This afforded 557.3 g (81percent yield) of 1,2,4,5-tetraminobenzene tetrahydrochloride.; The 1,2,4,5-tetraminobenzene tetrahydrochloride can be further purified by crystallization from aqueous with concentrated hydrochloric acid.
Reference: [1] Patent: US2014/66629, 2014, A1, . Location in patent: Paragraph 0073-0075
[2] Journal of Organic Chemistry, 2015, vol. 80, # 10, p. 5210 - 5217
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Reference: [1] Organic Letters, 2010, vol. 12, # 15, p. 3340 - 3343
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  • [ 1236133-47-3 ]
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Reference: [1] Organic Letters, 2010, vol. 12, # 15, p. 3340 - 3343
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