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Chemical Structure| 42443-15-2 Chemical Structure| 42443-15-2

Structure of 42443-15-2

Chemical Structure| 42443-15-2

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Product Details of [ 42443-15-2 ]

CAS No. :42443-15-2
Formula : C10H10BrNO2
M.W : 256.10
SMILES Code : BrC(C=C12)=C(O)C=C1CCN2C(C)=O
MDL No. :MFCD23099808

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Application In Synthesis of [ 42443-15-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 42443-15-2 ]

[ 42443-15-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 4770-32-5 ]
  • [ 42443-15-2 ]
YieldReaction ConditionsOperation in experiment
25% With N-Bromosuccinimide; acetic acid; at 10 - 20℃; for 1h; To a solution of the title compound from step 3 (3.0 g, 16.95 mmol) in AcOH (25 mL) was added a solution of NBS (3.01 g, 16.95 mmol) in AcOH (25 mL) slowly at 10C-20C. The mixture was stirred at that temperature for 1 hr. It was then poured over water (50 ml) and extracted with CH2CI2 (200 ml x 5). The combined organic phases were washed with brine, dried over Na2S04, filtered and concentrated. The residue was purified by column chromatography (PE: EA=10: 1-1: 1) to provide the title compound (1.10 g, 25% yield) as a solid. H NMR (DMSO-d6, 400 MHz) delta 9.90 (s, 1 H), 8.14 (s, 1 H), 6.83 (s, 1 H), 4.05 (t, J=8.4 Hz, 2 H), 3.04 (t, J = 8.4 Hz, 2 H), 2.11 (s, 3 H). LCMS: 256.0, 258.0 [M+H]+.
 

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