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Chemical Structure| 407623-72-7 Chemical Structure| 407623-72-7

Structure of 407623-72-7

Chemical Structure| 407623-72-7

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Product Details of [ 407623-72-7 ]

CAS No. :407623-72-7
Formula : C11H16N2O3
M.W : 224.26
SMILES Code : O=C(NC1C=CN=CC=1CO)OC(C)(C)C
MDL No. :MFCD04035600
InChI Key :FNGDRRWCPLWUDZ-UHFFFAOYSA-N
Pubchem ID :29920835

Safety of [ 407623-72-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 407623-72-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 407623-72-7 ]

[ 407623-72-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 138116-34-4 ]
  • [ 407623-72-7 ]
YieldReaction ConditionsOperation in experiment
In dichloromethane; at 20℃; for 1.0h; To a solution of 4-aminopyridme-3-methanol (3) (Alfa Aesar) (806 mg. 6.5 mmol) in ( I LCh (10 mL) a solution of di-tert-butyl-dicarbonate (1.43 g, 6.56 mmol) in Ci hC 'h (5 mL) was added and stirred at room temperature for 1 h (TLC), After 1 h, the solution was acidified with 1 N HQ (7.4 mL, 7.4 mmol). The phases were separated and the aqueous phase was washed with CH2CI2. The aqueous layer was mixed with a fresh portion of CH2CI2 (10 mL) and treated with K2CO3 (71 1 mg, 5.1 mmol). The phases were separated and treated with additional amounts of CH2G2.. The combined organic extracts were dried (MgS04) and evaporated in vacuo to give a 60:40 mixture containing desired product 8 and the O-linked carbonate. Attempts to purify the N-carbamate by flash chromatography from the O- carbonate were unsuccessful due interconversion between these two species in solution at room temperature. -N ViR (CDC13, 500 MHz) delta: 1.53 (91 L s), 4.67 (2H, s), 4.83 (2H, br s), 7.95 ( i i . s), 8.07 (1H, d, ./ 5.5 Hz), 8.28 (I H, d, J ------ 5.5 Hz), 8.48 (1 H, s). This product has been previously synthesized through a different route (Mochizuki, et al, 2011).
 

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