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Chemical Structure| 40492-53-3 Chemical Structure| 40492-53-3

Structure of 40492-53-3

Chemical Structure| 40492-53-3

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Product Details of [ 40492-53-3 ]

CAS No. :40492-53-3
Formula : C8H7BrO2
M.W : 215.04
SMILES Code : OC1=C(Br)C=C(OCC2)C2=C1
MDL No. :MFCD17169510

Safety of [ 40492-53-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 40492-53-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 40492-53-3 ]

[ 40492-53-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 40492-52-2 ]
  • [ 40492-53-3 ]
YieldReaction ConditionsOperation in experiment
With bromine; In dichloromethane; EXAMPLE 16 2,3-dihydro-6-bromo-5-benzofuranol (16) A 3 liter 3-neck flask fitted with a mechanical stirrer was charged with 1 (100 g, 735 mmol) in methylene chloride (1500 mL) and a solution of bromine (122 g, 763 mmol) in dichloromethane (total volume 250 mL) was added dropwise over 1.5 hours. Upon completion of the addition the mixture was allowed to stir at room temperature then worked up in two batches as follows. Approximately half of the reaction mixture was poured into 5% NaHCO3 (2000 mL) and the resulting mixture allowed to stir for 30 to 60 minutes. The layers were separated and the aqueous layer reextracted with methylene chloride (500 mL). The combined organic extracts were washed with 5% NaHSO3 (500 mL), dried with MgSO4, filtered and all the organic fractions combined. The product crystallized upon concentration and were therefore triturated in small batches to afford 16 as a tan solid.
 

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