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Chemical Structure| 40350-84-3 Chemical Structure| 40350-84-3

Structure of 40350-84-3

Chemical Structure| 40350-84-3

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Product Details of [ 40350-84-3 ]

CAS No. :40350-84-3
Formula : C12H15NO3
M.W : 221.25
SMILES Code : O=C([C@H]1NC[C@H](OCC2=CC=CC=C2)C1)O
MDL No. :MFCD08275792

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Application In Synthesis of [ 40350-84-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 40350-84-3 ]

[ 40350-84-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 40350-83-2 ]
  • [ 40350-84-3 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; In 1,4-dioxane; for 12h; General procedure: Synthesis of 1m-p 200 mg (0.86 mmol) of (2S,4R), (2S,4S), (2R,4R), or (2R,4S)-Boc-Hyp was dissolved in 3 ml of tetrahydrofuran, cooled to 0 C., and 103 mg (3 eq.) of 60% sodium hydride was added. The mixture was stirred cold for 20 minutes, then 226 ul (2.2 eq) of benzyl bromide was added. The mixture was allowed to warm to room temperature and stirred for 16 hours, at which time it was cooled to 0 C. and 1 ml of water was added, followed by 500 uL of 5% citric acid and 2 mL of saturated sodium bicarbonate solution. The organic layer was separated, and the aqueous phase was washed twice with 1 ml portions of ethyl acetate. The aqueous layer was then acidified to pH2.0 with citric acid, and extracted three times with 2 ml portions of ethyl acetate. The combined organic layers were washed with saturated sodium chloride solution, the solvent removed under reduced pressure, the residues were dissolved in 2 ml of methylene chloride, and 2 ml of 4M HCl in dioxane was added. The mixture was stirred for 12 hours, and the solvent removed under reduced pressure, yielding the HCl salts 3m-p. 300 uM of each was then converted first to 5m-p, then the final product 1m-p as the TFA salt via the methods described earlier for 1h-1.
 

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