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Chemical Structure| 38205-55-9 Chemical Structure| 38205-55-9

Structure of CYP2E1 inhibitor Q11
CAS No.: 38205-55-9

Chemical Structure| 38205-55-9

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Product Details of [ 38205-55-9 ]

CAS No. :38205-55-9
Formula : C6H7NOS
M.W : 141.19
SMILES Code : CC(C1=C(C)N=CS1)=O
MDL No. :MFCD09029046
InChI Key :MBLHLRLBSIWLMG-UHFFFAOYSA-N
Pubchem ID :162292

Safety of [ 38205-55-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 38205-55-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 38205-55-9 ]

[ 38205-55-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 30748-47-1 ]
  • [ 110-46-3 ]
  • [ 38205-55-9 ]
YieldReaction ConditionsOperation in experiment
In tetrahydrofuran; N-methyl-acetamide; di-isopropyl ether; water; ethyl acetate; EXAMPLE 119 To a solution of <strong>[30748-47-1]5-acetyl-2-amino-4-methylthiazole</strong> (15.6 g) in a mixture of tetrahydrofuran (200 ml) and dimethylformamide (50 ml) was dropwise added isoamylnitrite (14.6 g) at 50 C. to 55 C. with stirring and the mixture was stirred at 55 C. to 60 C. for 4 hours. The reaction mixture was poured into a mixture of ethyl acetate and water with stirring. The separated organic layer was washed with brine, dried over magnesium sulfate, and evaporated in vacuo. The residue was subjected to column chromatography on silica gel and eluted with a mixture of diisopropyl ether and ethyl acetate (1:1). The fractions containing the desired compound were combined and evaporated in vacuo to give 5-acetyl-4-methylthiazole (7.7 g) as an oil. IR (Film): 1660 cm-1 NMR (DMSO-d6, δ): 2.56 (3H, s), 2.68 (3H, s), 9.16 (1H, s)
 

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